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Ttll5 Gene Detail
Summary
  • Symbol
    Ttll5
  • Name
    tubulin tyrosine ligase-like family, member 5
  • Synonyms
    1700048H13Rik, 2310009M18Rik, 4930556H18Rik, D630041K24Rik, mKIAA0998, STAMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443657
    NCBI Gene: 320244
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85871417-86100534 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.81 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5010 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443657
 protein coding gene Chr12:85871417-86108667 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019966
 protein coding gene Chr12:86632292-86874020 (+)
A/J MGP_AJ_G0019923
 protein coding gene Chr12:83336920-83573594 (+)
AKR/J MGP_AKRJ_G0019899
 protein coding gene Chr12:85589120-85829908 (+)
BALB/cJ MGP_BALBcJ_G0019903
 protein coding gene Chr12:83674319-83912808 (+)
C3H/HeJ MGP_C3HHeJ_G0019709
 protein coding gene Chr12:86073612-86326218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020354
 protein coding gene Chr12:89123887-89369930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017972
 protein coding gene Chr12:80227720-80461084 (+)
CAST/EiJ MGP_CASTEiJ_G0019259
 protein coding gene Chr12:81056143-81302050 (+)
CBA/J MGP_CBAJ_G0019680
 protein coding gene Chr12:92549270-92802671 (+)
DBA/2J MGP_DBA2J_G0019794
 protein coding gene Chr12:82847978-83083734 (+)
FVB/NJ MGP_FVBNJ_G0019781
 protein coding gene Chr12:81818031-82052109 (+)
LP/J MGP_LPJ_G0019868
 protein coding gene Chr12:86507397-86754190 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019820
 protein coding gene Chr12:95366299-95608251 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020387
 protein coding gene Chr12:85204237-85459152 (+)
PWK/PhJ MGP_PWKPhJ_G0019022
 protein coding gene Chr12:77366289-77606943 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018818
 protein coding gene Chr12:79693518-79938308 (+)
WSB/EiJ MGP_WSBEiJ_G0019311
 protein coding gene Chr12:85946696-86189899 (+)



Homology
more
  • Human Ortholog
    TTLL5, tubulin tyrosine ligase like 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTLL5, tubulin tyrosine ligase like 5
  • Synonyms
    CORD19, KIAA0998, STAMP
  • Links
    NCBI Gene ID: 23093
    neXtProt AC: NX_Q6EMB2
    UniProt: Q6EMB2

  • Chr Location
    14q24.3; chr14:75633625-75955079 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TTLL5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit male infertility associated with abnormal sperm morphology and reduced tubulin polyglutamylation in the spermatozoa.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    6
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320244 NCBI Gene Model | MGI Sequence Detail 229118 C57BL/6J ±  kb
    transcript NM_001081423 RefSeq | MGI Sequence Detail 4871 C57BL/6  
    polypeptide Q8CHB8 UniProt | EBI | MGI Sequence Detail 1328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916810, MGI:1920622, MGI:1922613, MGI:2144819, MGI:2145136
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:323874 Wu HY, et al., TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice. PLoS Genet. 2022 Apr;18(4):e1010144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory