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Rreb1 Gene Detail
Summary
  • Symbol
    Rreb1
  • Name
    ras responsive element binding protein 1
  • Synonyms
    1110037N09Rik, B930013M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443664
    NCBI Gene: 68750
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:37962376-38135981 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443664
 protein coding gene Chr13:37962362-38135981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020466
 protein coding gene Chr13:36072702-36260718 (+)
A/J MGP_AJ_G0020420
 protein coding gene Chr13:34944372-35121408 (+)
AKR/J MGP_AKRJ_G0020398
 protein coding gene Chr13:35871115-36047774 (+)
BALB/cJ MGP_BALBcJ_G0020416
 protein coding gene Chr13:35043876-35220276 (+)
C3H/HeJ MGP_C3HHeJ_G0020215
 protein coding gene Chr13:35693773-35876999 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020849
 protein coding gene Chr13:37256013-37444021 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018436
 protein coding gene Chr13:33124048-33301691 (+)
CAST/EiJ MGP_CASTEiJ_G0019730
 protein coding gene Chr13:35450210-35636893 (+)
CBA/J MGP_CBAJ_G0020176
 protein coding gene Chr13:38831799-39034071 (+)
DBA/2J MGP_DBA2J_G0020298
 protein coding gene Chr13:34466860-34642344 (+)
FVB/NJ MGP_FVBNJ_G0020277
 protein coding gene Chr13:34004073-34182086 (+)
LP/J MGP_LPJ_G0020373
 protein coding gene Chr13:36320775-36503421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020307
 protein coding gene Chr13:38961719-39146899 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020892
 protein coding gene Chr13:35435840-35620340 (+)
PWK/PhJ MGP_PWKPhJ_G0019485
 protein coding gene Chr13:34579493-34763271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019316
 protein coding gene Chr13:34096050-34279349 (+)
WSB/EiJ MGP_WSBEiJ_G0019792
 protein coding gene Chr13:35783991-35969187 (+)



Homology
more
  • Human Ortholog
    RREB1, ras responsive element binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RREB1, ras responsive element binding protein 1
  • Synonyms
    FINB, HNT, LZ321, RREB-1, Zep-1
  • Links
    NCBI Gene ID: 6239
    neXtProt AC: NX_Q92766
    UniProt: Q92766

  • Chr Location
    6p24.3; chr6:7107597-7251980 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rreb1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality before E9.5. Heterozygotes exhibit smaller stature, orbital hypertelorism, wider blunted nose, cardiac hypertrophy and decreased cardiac function. A spontaneous hypomorph that disrupts only the V7 transcript causes progressive Purkinje cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    30
  • cDNA Data
    18
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039087 Ensembl Gene Model | MGI Sequence Detail 173606 C57BL/6J ±  kb
    transcript ENSMUST00000037232 Ensembl | MGI Sequence Detail 8395 Not Applicable  
    polypeptide ENSMUSP00000049265 Ensembl | MGI Sequence Detail 1754 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916000, MGI:2145160, MGI:5008647
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:358146 Han G, et al., Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance. Cell Stem Cell. 2024 Sep 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory