About   Help   FAQ
Arhgap25 Gene Detail
Summary
  • Symbol
    Arhgap25
  • Name
    Rho GTPase activating protein 25
  • Synonyms
    A130039I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443687
    NCBI Gene: 232201
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87435527-87510241 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 38.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443687
 protein coding gene Chr6:87435526-87510241 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030993
 protein coding gene Chr6:88805393-88885718 (-)
A/J MGP_AJ_G0030959
 protein coding gene Chr6:85372737-85451293 (-)
AKR/J MGP_AKRJ_G0030890
 protein coding gene Chr6:87843738-87921735 (-)
BALB/cJ MGP_BALBcJ_G0030972
 protein coding gene Chr6:85374798-85452190 (-)
C3H/HeJ MGP_C3HHeJ_G0030738
 protein coding gene Chr6:96544417-96623572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031429
 protein coding gene Chr6:91192925-91268428 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028613
 protein coding gene Chr6:83556796-83632465 (-)
CAST/EiJ MGP_CASTEiJ_G0030081
 protein coding gene Chr6:87923068-88004199 (-)
CBA/J MGP_CBAJ_G0030656
 protein coding gene Chr6:94730910-94807763 (-)
DBA/2J MGP_DBA2J_G0030812
 protein coding gene Chr6:84678597-84757813 (-)
FVB/NJ MGP_FVBNJ_G0030765
 protein coding gene Chr6:83861387-83938091 (-)
LP/J MGP_LPJ_G0030889
 protein coding gene Chr6:88822241-88905012 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030798
 protein coding gene Chr6:98860399-98941574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031456
 protein coding gene Chr6:87687642-87767993 (-)
PWK/PhJ MGP_PWKPhJ_G0029796
 protein coding gene Chr6:83641548-83720096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029624
 protein coding gene Chr6:86504115-86580038 (-)
WSB/EiJ MGP_WSBEiJ_G0030162
 protein coding gene Chr6:88147717-88228457 (-)



Homology
more
  • Human Ortholog
    ARHGAP25, Rho GTPase activating protein 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP25, Rho GTPase activating protein 25
  • Synonyms
    HEL-S-308, KAIA0053
  • Links
    NCBI Gene ID: 9938
    neXtProt AC: NX_P42331
    UniProt: P42331

  • Chr Location
    2p13.3; chr2:68679601-68826833 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered leukocyte transendothelial migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    8
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030047 Ensembl Gene Model | MGI Sequence Detail 74715 C57BL/6J ±  kb
    transcript ENSMUST00000113637 Ensembl | MGI Sequence Detail 3671 Not Applicable  
    polypeptide ENSMUSP00000109267 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory