Tafa1 MGI Mouse Gene Detail - MGI:2443695 - TAFA chemokine like family member 1

Symbol

Tafa1
Name

TAFA chemokine like family member 1
Synonyms

C630007B19Rik, Fam19a1, Tafa-1

Feature Type

protein coding gene
IDs

MGI:2443695
NCBI Gene: 320265
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr6:96090135-96634159 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 44.67 cM
Mapping Data

1 experiment

SNPs within 2kb

14242 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443695	protein coding gene	Chr6:96090135-96634169 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031069	protein coding gene	Chr6:97924630-98474153 (+)
A/J	MGP_AJ_G0031038	protein coding gene	Chr6:94211360-94751296 (+)
AKR/J	MGP_AKRJ_G0030969	protein coding gene	Chr6:96802645-97357961 (+)
BALB/cJ	MGP_BALBcJ_G0031049	protein coding gene	Chr6:94155334-94703968 (+)
C3H/HeJ	MGP_C3HHeJ_G0030658	protein coding gene	Chr6:87059693-87630299 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031508	protein coding gene	Chr6:100363783-100961220 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028673	protein coding gene	Chr6:92107589-92630022 (+)
CAST/EiJ	MGP_CASTEiJ_G0030156	protein coding gene	Chr6:97004313-97556756 (+)
CBA/J	MGP_CBAJ_G0030735	protein coding gene	Chr6:104181051-104777082 (+)
DBA/2J	MGP_DBA2J_G0030888	protein coding gene	Chr6:93358520-93888891 (+)
FVB/NJ	MGP_FVBNJ_G0030842	protein coding gene	Chr6:92545332-93079709 (+)
LP/J	MGP_LPJ_G0030968	protein coding gene	Chr6:97929545-98496383 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030876	protein coding gene	Chr6:108160245-108744250 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031535	protein coding gene	Chr6:96669483-97233202 (+)
PWK/PhJ	MGP_PWKPhJ_G0029872	protein coding gene	Chr6:92364607-92897988 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029700	protein coding gene	Chr6:95601082-96145285 (+)
WSB/EiJ	MGP_WSBEiJ_G0030240	protein coding gene	Chr6:97139198-97699570 (+)

Human Ortholog

TAFA1, TAFA chemokine like family member 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAFA1, TAFA chemokine like family member 1
Synonyms

FAM19A1, TAFA-1
Links

HGNC:21587

NCBI Gene ID: 407738

neXtProt AC: NX_Q7Z5A9

UniProt: Q7Z5A9
Chr Location

3p14.1; chr3:67991544-68545621 (+) GRCh38

MGI Vertebrate Homology

Tafa1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TAFA1
Gene Tree

Tafa1

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Tafa1
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit sex-dependent alterations in food intake patterns, locomotor activity, anxiety-like behavior, dopamine turnover, and sensitivity to pain induced by heat or electric shock.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

872
Tissues

75
cDNA Data

4
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS39574.1

Ensembl

ENSMUSG00000059187 (Evidence)
NCBI Gene

320265

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059187	Ensembl Gene Model \| MGI Sequence Detail	544025	C57BL/6J	± kb
transcript	ENSMUST00000122120	Ensembl \| MGI Sequence Detail	3252	Not Applicable
polypeptide	ENSMUSP00000113152	Ensembl \| MGI Sequence Detail	133	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030989 chemokine-like protein TAFA-1

(term hierarchy)
InterPro Domains

IPR020350 Chemokine-like protein TAFA

IPR051743 TAFA chemokine-like

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All nucleic 6

cDNA 4

Primer pair 1

Other 1

Microarray probesets 3

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MGI:6276241

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 15
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tafa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57824	Chr6:96090087-96090098 (+)	-42 bp
Tssr57825	Chr6:96090099-96090108 (+)	-31 bp
Tssr57826	Chr6:96090127-96090151 (+)	4 bp
Tssr57827	Chr6:96090429-96090433 (+)	296 bp
Tssr57828	Chr6:96092230-96092252 (+)	2,106 bp
Tssr57829	Chr6:96103630-96103644 (+)	13,502 bp
Tssr57830	Chr6:96117761-96117783 (+)	27,637 bp
Tssr57831	Chr6:96230791-96230794 (+)	140,658 bp
Tssr57832	Chr6:96235600-96235615 (+)	145,473 bp
Tssr57833	Chr6:96259402-96259405 (+)	169,269 bp
Tssr57834	Chr6:96334069-96334091 (+)	243,945 bp
Tssr57835	Chr6:96352334-96352343 (+)	262,204 bp
Tssr57836	Chr6:96354795-96354799 (+)	264,662 bp
Tssr57837	Chr6:96376604-96376625 (+)	286,480 bp
Tssr57838	Chr6:96569948-96569949 (+)	479,814 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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