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Lrig2 Gene Detail
Summary
  • Symbol
    Lrig2
  • Name
    leucine-rich repeats and immunoglobulin-like domains 2
  • Synonyms
    4632419I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443718
    NCBI Gene: 269473
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104361296-104419251 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    934 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443718
 protein coding gene Chr3:104303734-104419251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027706
 protein coding gene Chr3:105695145-105820968 (-)
A/J MGP_AJ_G0027666
 protein coding gene Chr3:102338755-102459046 (-)
AKR/J MGP_AKRJ_G0027631
 protein coding gene Chr3:104852356-104976744 (-)
BALB/cJ MGP_BALBcJ_G0027678
 protein coding gene Chr3:102115629-102230200 (-)
C3H/HeJ MGP_C3HHeJ_G0027408
 protein coding gene Chr3:105218646-105344830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028122
 protein coding gene Chr3:109626935-109754145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025462
 protein coding gene Chr3:98465537-98576818 (-)
CAST/EiJ MGP_CASTEiJ_G0026864
 protein coding gene Chr3:104341410-104461152 (-)
CBA/J MGP_CBAJ_G0027383
 protein coding gene Chr3:113373871-113509716 (-)
DBA/2J MGP_DBA2J_G0027525
 protein coding gene Chr3:101589728-101705335 (-)
FVB/NJ MGP_FVBNJ_G0027493
 protein coding gene Chr3:99518755-99634610 (-)
LP/J MGP_LPJ_G0027632
 protein coding gene Chr3:107051736-107180513 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027523
 protein coding gene Chr3:119514607-119639042 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028177
 protein coding gene Chr3:104409595-104534092 (-)
PWK/PhJ MGP_PWKPhJ_G0026590
 protein coding gene Chr3:101374233-101491858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026411
 protein coding gene Chr3:102457806-102581827 (-)
WSB/EiJ MGP_WSBEiJ_G0026944
 protein coding gene Chr3:104972108-105098425 (-)



Homology
more
  • Human Ortholog
    LRIG2, leucine rich repeats and immunoglobulin like domains 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRIG2, leucine rich repeats and immunoglobulin like domains 2
  • Synonyms
    LIG-2, LIG2, UFS2
  • Links
    NCBI Gene ID: 9860
    neXtProt AC: NX_O94898
    UniProt: O94898

  • Chr Location
    1p13.2; chr1:113073198-113132260 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LRIG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced susceptibility to PDGFB-induced glioma and premature death due to illness with reduced body weight, letahrgy, hackled fur, crouched posture and increased inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    84
  • cDNA Data
    81
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269473 NCBI Gene Model | MGI Sequence Detail 57956 C57BL/6J ±  kb
    transcript NM_001025067 RefSeq | MGI Sequence Detail 7196 C57BL/6  
    polypeptide Q52KR2 UniProt | EBI | MGI Sequence Detail 1054 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031211 leucine-rich repeats and immunoglobulin-like domains protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q52KR2 13 sites, 5 N-linked glycans (9 sites)
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 82
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140022
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory