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Intu Gene Detail
Summary
  • Symbol
    Intu
  • Name
    inturned planar cell polarity protein
  • Synonyms
    9230116I04Rik, 9430087H23Rik, mKIAA1284, Pdzd6, Pdzk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443752
    NCBI Gene: 380614
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:40585559-40659206 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 19.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443752
 protein coding gene Chr3:40585435-40659206 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027177
 protein coding gene Chr3:38488659-38666922 (+)
A/J MGP_AJ_G0027137
 protein coding gene Chr3:37646231-37719858 (+)
AKR/J MGP_AKRJ_G0027106
 protein coding gene Chr3:38365338-38438638 (+)
BALB/cJ MGP_BALBcJ_G0027149
 protein coding gene Chr3:37400425-37475146 (+)
C3H/HeJ MGP_C3HHeJ_G0026892
 protein coding gene Chr3:38446826-38525206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027595
 protein coding gene Chr3:40171091-40253121 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024956
 protein coding gene Chr3:35210715-35286611 (+)
CAST/EiJ MGP_CASTEiJ_G0026345
 protein coding gene Chr3:38346768-38426073 (+)
CBA/J MGP_CBAJ_G0026869
 protein coding gene Chr3:41346971-41425540 (+)
DBA/2J MGP_DBA2J_G0027003
 protein coding gene Chr3:37105734-37180537 (+)
FVB/NJ MGP_FVBNJ_G0026971
 protein coding gene Chr3:36507030-36586886 (+)
LP/J MGP_LPJ_G0027115
 protein coding gene Chr3:39326127-39407807 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026990
 protein coding gene Chr3:43783424-43869660 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027654
 protein coding gene Chr3:38244177-38327938 (+)
PWK/PhJ MGP_PWKPhJ_G0026078
 protein coding gene Chr3:36765842-36842300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025890
 protein coding gene Chr3:37598169-37671915 (+)
WSB/EiJ MGP_WSBEiJ_G0026419
 protein coding gene Chr3:38245925-38324342 (+)



Homology
more
  • Human Ortholog
    INTU, inturned planar cell polarity protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTU, inturned planar cell polarity protein
  • Synonyms
    CPLANE4, INT, OFD17, PDZD6, PDZK6, SRTD20
  • Links
    NCBI Gene ID: 27152
    neXtProt AC: NX_Q9ULD6
    UniProt: Q9ULD6

  • Chr Location
    4q28.1; chr4:127623271-127726737 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human INTU associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show defective ciliogenesis and neural tube closure, abnormal patterning of the CNS and limbs, polydactyly, edema and death by E16.5. Homozygotes for a hypomorphic allele show defective ciliation and endochondral ossification, stunted growth, polydactyly and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    29
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380614 NCBI Gene Model | MGI Sequence Detail 73648 C57BL/6J ±  kb
    transcript NM_001405498 RefSeq | MGI Sequence Detail 6698 C57BL/6  
    polypeptide Q059U7 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925153
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:352479 Zeng H, et al., CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling. Dev Biol. 2024 Jul 17;515:92-101
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory