Rnf152 MGI Mouse Gene Detail - MGI:2443787

Symbol

Rnf152
Name

ring finger protein 152
Synonyms

A930029B02Rik

Feature Type

protein coding gene
IDs

MGI:2443787
NCBI Gene: 320311
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:105204639-105284435 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 49.45 cM
Mapping Data

1 experiment

SNPs within 2kb

2282 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443787	protein coding gene	Chr1:105204639-105284665 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016365	protein coding gene	Chr1:107367762-107457817 (-)
A/J	MGP_AJ_G0016349	protein coding gene	Chr1:103643717-103728082 (-)
AKR/J	MGP_AKRJ_G0016309	protein coding gene	Chr1:106470631-106558677 (-)
BALB/cJ	MGP_BALBcJ_G0016305	protein coding gene	Chr1:103737993-103818364 (-)
C3H/HeJ	MGP_C3HHeJ_G0016132	protein coding gene	Chr1:106891086-106980104 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016764	protein coding gene	Chr1:111524636-111606792 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014482	protein coding gene	Chr1:98013662-98089525 (-)
CAST/EiJ	MGP_CASTEiJ_G0015714	protein coding gene	Chr1:105825737-105904988 (-)
CBA/J	MGP_CBAJ_G0016105	protein coding gene	Chr1:115272369-115364901 (-)
DBA/2J	MGP_DBA2J_G0016210	protein coding gene	Chr1:102697341-102783946 (-)
FVB/NJ	MGP_FVBNJ_G0016211	protein coding gene	Chr1:101657086-101736739 (-)
LP/J	MGP_LPJ_G0016284	protein coding gene	Chr1:108635506-108723874 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016237	protein coding gene	Chr1:119728262-119825211 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016803	protein coding gene	Chr1:106551823-106636457 (-)
PWK/PhJ	MGP_PWKPhJ_G0015501	protein coding gene	Chr1:101757383-101840601 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015286	protein coding gene	Chr1:105208600-105287386 (-)
WSB/EiJ	MGP_WSBEiJ_G0015777	protein coding gene	Chr1:106384026-106469134 (-)

Human Ortholog

RNF152, ring finger protein 152

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF152, ring finger protein 152
Links

HGNC:26811

NCBI Gene ID: 220441

neXtProt AC: NX_Q8N8N0

UniProt: Q8N8N0
Chr Location

18q21.33; chr18:61808067-61894412 (-) GRCh38

MGI Vertebrate Homology

Rnf152 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF152
Gene Tree

Rnf152

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving Rnf152
Incidental Mutations

CvDC
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a null mutation display reduced starvation induced autophagy in MEFs.

less

All GO Annotations

35
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

34
cDNA Data

23
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf152

ZFIN rnf152

less

All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS15204.1

Ensembl

ENSMUSG00000047496 (Evidence)
NCBI Gene

320311

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047496	Ensembl Gene Model \| MGI Sequence Detail	79797	C57BL/6J	± kb
transcript	ENSMUST00000058688	Ensembl \| MGI Sequence Detail	8492	Not Applicable
polypeptide	ENSMUSP00000050103	Ensembl \| MGI Sequence Detail	203	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000014095 E3 ubiquitin-protein ligase RNF152

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR045744 E3 ubiquitin-protein ligase RNF152, C-terminal

IPR033609 E3 ubiquitin-protein ligase RNF152, RING finger domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

less

All nucleic 25

Genomic 2

cDNA 23

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:285783 Xiong MG, et al., RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. EMBO Rep. 2020 Mar 4;21(3):e48860

TSS for Rnf152:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13130	Chr1:105284659-105284688 (-)	-239 bp
Tssr13129	Chr1:105284494-105284513 (-)	-69 bp
Tssr13128	Chr1:105284383-105284439 (-)	24 bp
Tssr13127	Chr1:105284365-105284376 (-)	64 bp
Tssr13126	Chr1:105284205-105284241 (-)	212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24