Rasal2 MGI Mouse Gene Detail - MGI:2443881 - RAS protein activator like 2

Symbol

Rasal2
Name

RAS protein activator like 2
Synonyms

A330066M24Rik

Feature Type

protein coding gene
IDs

MGI:2443881
NCBI Gene: 226525
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:156962759-157240170 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.97 cM
Mapping Data

1 experiment

SNPs within 2kb

5993 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443881	protein coding gene	Chr1:156962752-157240170 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016631	protein coding gene	Chr1:162141166-162443033 (-)
A/J	MGP_AJ_G0016612	protein coding gene	Chr1:155610668-155890409 (-)
AKR/J	MGP_AKRJ_G0016578	protein coding gene	Chr1:160360737-160652455 (-)
BALB/cJ	MGP_BALBcJ_G0016573	protein coding gene	Chr1:156112395-156391089 (-)
C3H/HeJ	MGP_C3HHeJ_G0016397	protein coding gene	Chr1:160495042-160791677 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017034	protein coding gene	Chr1:167699360-168011409 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014743	protein coding gene	Chr1:147805762-148075020 (-)
CAST/EiJ	MGP_CASTEiJ_G0015977	protein coding gene	Chr1:160058222-160334607 (-)
CBA/J	MGP_CBAJ_G0016372	protein coding gene	Chr1:173635385-173956428 (-)
DBA/2J	MGP_DBA2J_G0016478	protein coding gene	Chr1:154558177-154836363 (-)
FVB/NJ	MGP_FVBNJ_G0016476	protein coding gene	Chr1:153013901-153285600 (-)
LP/J	MGP_LPJ_G0016549	protein coding gene	Chr1:163274222-163557731 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016501	protein coding gene	Chr1:181139458-181494050 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017070	protein coding gene	Chr1:160185139-160479767 (-)
PWK/PhJ	MGP_PWKPhJ_G0015763	protein coding gene	Chr1:153658827-153941707 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015550	protein coding gene	Chr1:158922375-159216811 (-)
WSB/EiJ	MGP_WSBEiJ_G0016039	protein coding gene	Chr1:160293464-160590028 (-)

Human Ortholog

RASAL2, RAS protein activator like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASAL2, RAS protein activator like 2
Synonyms

NGAP
Links

HGNC:9874

NCBI Gene ID: 9462

neXtProt AC: NX_Q9UJF2

UniProt: Q9UJF2
Chr Location

1q25.2; chr1:178094104-178484147 (+) GRCh38

MGI Vertebrate Homology

Rasal2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASAL2
Gene Tree

Rasal2

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

4
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Rasal2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available

Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. In other tumorigenic models, this allele promotes increase metastatic potential.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

883
Tissues

22
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasal2

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All Sequences

75
RefSeq

20
UniProt

8
CCDS

CCDS48408.1

Ensembl

ENSMUSG00000070565 (Evidence)
NCBI Gene

226525

			Length	Strain/Species	Flank
genomic	226525	NCBI Gene Model \| MGI Sequence Detail	277412	C57BL/6J	± kb
transcript	NM_177644	RefSeq \| MGI Sequence Detail	9979	C57BL/6
polypeptide	NP_808312	RefSeq \| MGI Sequence Detail	1286	C57BL/6

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UniProt

8 Sequences
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR021887 Disabled homolog 2-interacting protein, C-terminal domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001936 Ras GTPase-activating domain

IPR039360 Ras GTPase-activating protein

IPR023152 Ras GTPase-activating protein, conserved site

IPR008936 Rho GTPase activation protein
GlyGen

E9PW37 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

cDNA 16

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 14
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rasal2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14491	Chr1:157240146-157240191 (-)	1 bp
Tssr14490	Chr1:157240097-157240135 (-)	54 bp
Tssr14489	Chr1:157239828-157239872 (-)	320 bp
Tssr259	Chr1:157225803-157225811 (-)	14,363 bp
Tssr14488	Chr1:157159965-157159970 (-)	80,202 bp
Tssr14487	Chr1:157084389-157084411 (-)	155,770 bp
Tssr257	Chr1:157084345-157084357 (-)	155,819 bp
Tssr14486	Chr1:157084273-157084295 (-)	155,886 bp
Tssr14485	Chr1:157084261-157084271 (-)	155,904 bp
Tssr14484	Chr1:157084197-157084220 (-)	155,961 bp
Tssr14483	Chr1:157072076-157072127 (-)	168,068 bp
Tssr14482	Chr1:157072040-157072075 (-)	168,112 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24