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Nell1 Gene Detail
Summary
  • Symbol
    Nell1
  • Name
    NEL-like 1
  • Synonyms
    B230343H07Rik, l7R6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443902
    NCBI Gene: 338352
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:49625098-50513037 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24552 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443902
 protein coding gene Chr7:49624612-50516356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032302
 protein coding gene Chr7:50668884-51582469 (+)
A/J MGP_AJ_G0032281
 protein coding gene Chr7:49900117-50758466 (+)
AKR/J MGP_AKRJ_G0032217
 protein coding gene Chr7:51093815-51971922 (+)
BALB/cJ MGP_BALBcJ_G0032293
 protein coding gene Chr7:49569156-50444504 (+)
C3H/HeJ MGP_C3HHeJ_G0032006
 protein coding gene Chr7:51461492-52374961 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032786
 protein coding gene Chr7:52970624-53919363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029792
 protein coding gene Chr7:53067573-53876732 (+)
CAST/EiJ MGP_CASTEiJ_G0031334
 protein coding gene Chr7:42878438-43770453 (+)
CBA/J MGP_CBAJ_G0031971
 protein coding gene Chr7:54764910-55686844 (+)
DBA/2J MGP_DBA2J_G0032128
 protein coding gene Chr7:49116385-49977793 (+)
FVB/NJ MGP_FVBNJ_G0032082
 protein coding gene Chr7:49052957-49909016 (+)
LP/J MGP_LPJ_G0032209
 protein coding gene Chr7:51605591-52518452 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032119
 protein coding gene Chr7:53851760-54813300 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032803
 protein coding gene Chr7:50073231-50965816 (+)
PWK/PhJ MGP_PWKPhJ_G0031054
 protein coding gene Chr7:42462977-43304934 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030895
 protein coding gene Chr7:38246826-39158540 (+)
WSB/EiJ MGP_WSBEiJ_G0031452
 protein coding gene Chr7:50727332-51655746 (+)



Homology
more
  • Human Ortholog
    NELL1, neural EGFL like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NELL1, neural EGFL like 1
  • Synonyms
    IDH3GL, NRP1
  • Links
    NCBI Gene ID: 4745
    neXtProt AC: NX_Q92832
    UniProt: Q92832

  • Chr Location
    11p15.1; chr11:20669551-21575686 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 10 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display perinatal lethality, respiratory failure, impaired development of the intervertebral disks, vertebrae and calvarial bones, increased skull length, and abnormal curvature of the spine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    68
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 338352 NCBI Gene Model | MGI Sequence Detail 887940 C57BL/6J ±  kb
    transcript NM_001037906 RefSeq | MGI Sequence Detail 2812 C57BL/6  
    polypeptide Q2VWQ2 UniProt | EBI | MGI Sequence Detail 810 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011137 protein kinase C-binding protein NELL1
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR024731 EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR051586 Protein kinase C-binding NELL
      IPR048287 Thrombospondin-like, N-terminal domain
      IPR001007 VWFC domain
    • GlyGen
      Q2VWQ2 12 sites, 6 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 15
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1890515
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:73982 Rinchik EM, et al., Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):844-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory