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Irf2bp2 Gene Detail
Summary
  • Symbol
    Irf2bp2
  • Name
    interferon regulatory factor 2 binding protein 2
  • Synonyms
    E130305N23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443921
    NCBI Gene: 270110
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:127315035-127320725 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 74.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443921
 protein coding gene Chr8:127315035-127320725 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034296
 protein coding gene Chr8:130421577-130428258 (-)
A/J MGP_AJ_G0034275
 protein coding gene Chr8:125004591-125010273 (-)
AKR/J MGP_AKRJ_G0034202
 protein coding gene Chr8:128602885-128608289 (-)
BALB/cJ MGP_BALBcJ_G0034268
 protein coding gene Chr8:125177622-125183644 (-)
C3H/HeJ MGP_C3HHeJ_G0033979
 protein coding gene Chr8:129245444-129250779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034788
 protein coding gene Chr8:134745851-134752676 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031730
 protein coding gene Chr8:117693711-117699521 (-)
CAST/EiJ MGP_CASTEiJ_G0033306
 protein coding gene Chr8:129422356-129428003 (-)
CBA/J MGP_CBAJ_G0033953
 protein coding gene Chr8:139744275-139749610 (-)
DBA/2J MGP_DBA2J_G0034108
 protein coding gene Chr8:124139794-124145619 (-)
FVB/NJ MGP_FVBNJ_G0034053
 protein coding gene Chr8:123361711-123367137 (-)
LP/J MGP_LPJ_G0034197
 protein coding gene Chr8:130571780-130579551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034099
 protein coding gene Chr8:141665740-141674202 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034807
 protein coding gene Chr8:128846148-128852962 (-)
PWK/PhJ MGP_PWKPhJ_G0033009
 protein coding gene Chr8:123844029-123922425 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032847
 protein coding gene Chr8:127471748-127478582 (-)
WSB/EiJ MGP_WSBEiJ_G0033424
 protein coding gene Chr8:129586158-129594676 (-)



Homology
more
  • Human Ortholog
    IRF2BP2, interferon regulatory factor 2 binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF2BP2, interferon regulatory factor 2 binding protein 2
  • Synonyms
    CVID14
  • Links
    NCBI Gene ID: 359948
    neXtProt AC: NX_Q7Z5L9
    UniProt: Q7Z5L9

  • Chr Location
    1q42.3; chr1:234604269-234610178 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRF2BP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are rarely born alive and those that are do not survive past 4 weeks of age. Fetal liver erythropoiesis is abnormal in these mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 270110 NCBI Gene Model | MGI Sequence Detail 5691 C57BL/6J ±  kb
    transcript NM_001164598 RefSeq | MGI Sequence Detail 5080 C57BL/6  
    polypeptide E9Q1P8 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009104 interferon regulatory factor 2-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR044882 Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily
      IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
    • GlyGen
      E9Q1P8 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 6
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:326618 Vilmundarson RO, et al., Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2-Null Mice. Front Immunol. 2022;13:868053
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory