Lrig3 MGI Mouse Gene Detail - MGI:2443955 - leucine-rich repeats and immunoglobulin-like domains 3

Symbol

Lrig3
Name

leucine-rich repeats and immunoglobulin-like domains 3
Synonyms

9030421L11Rik, 9130004I02Rik, 9430095K15Rik, mKIAA3016

Feature Type

protein coding gene
IDs

MGI:2443955
NCBI Gene: 320398
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:125802088-125851228 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 73.66 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

1397 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443955	protein coding gene	Chr10:125802037-125851228 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017795	protein coding gene	Chr10:129489870-129544795 (+)
A/J	MGP_AJ_G0017770	protein coding gene	Chr10:124306124-124359522 (+)
AKR/J	MGP_AKRJ_G0017733	protein coding gene	Chr10:127970043-128022282 (+)
BALB/cJ	MGP_BALBcJ_G0017734	protein coding gene	Chr10:124720731-124773786 (+)
C3H/HeJ	MGP_C3HHeJ_G0017558	protein coding gene	Chr10:128163669-128214577 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018189	protein coding gene	Chr10:133857363-133910146 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015869	protein coding gene	Chr10:118403017-118453000 (+)
CAST/EiJ	MGP_CASTEiJ_G0017118	protein coding gene	Chr10:128710821-128770620 (+)
CBA/J	MGP_CBAJ_G0017527	protein coding gene	Chr10:139269597-139324149 (+)
DBA/2J	MGP_DBA2J_G0017633	protein coding gene	Chr10:123403671-123456921 (+)
FVB/NJ	MGP_FVBNJ_G0017628	protein coding gene	Chr10:122348319-122398508 (+)
LP/J	MGP_LPJ_G0017707	protein coding gene	Chr10:130020746-130079823 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017656	protein coding gene	Chr10:141988272-142045591 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018229	protein coding gene	Chr10:128048862-128098453 (+)
PWK/PhJ	MGP_PWKPhJ_G0016903	protein coding gene	Chr10:123586123-123638951 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016695	protein coding gene	Chr10:127076391-127192926 (+)
WSB/EiJ	MGP_WSBEiJ_G0017179	protein coding gene	Chr10:128228549-128283280 (+)

Human Ortholog

LRIG3, leucine rich repeats and immunoglobulin like domains 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRIG3, leucine rich repeats and immunoglobulin like domains 3
Synonyms

LIG3
Links

HGNC:30991

NCBI Gene ID: 121227

neXtProt AC: NX_Q6UXM1

UniProt: Q6UXM1
Chr Location

12q14.1; chr12:58872149-58920504 (-) GRCh38

MGI Vertebrate Homology

Lrig3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRIG3
Gene Tree

Lrig3

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Phenotype Summary

39 phenotypes from 4 alleles in 5 genetic backgrounds
10 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

3
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele or severely hypomorphic gene trap allele exhibit fusion of the lateral semicircular canal and circling behavior.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

56
cDNA Data

40
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LRIG3

Xenbase lrig3

ZFIN lrig3

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All Sequences

47
RefSeq

2
UniProt

2
CCDS

CCDS24219.1

Ensembl

ENSMUSG00000020105 (Evidence)
NCBI Gene

320398

			Length	Strain/Species	Flank
genomic	320398	NCBI Gene Model \| MGI Sequence Detail	49141	C57BL/6J	± kb
transcript	NM_177152	RefSeq \| MGI Sequence Detail	4050	C57BL/6
polypeptide	Q6P1C6	UniProt \| EBI \| MGI Sequence Detail	1117	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032013 leucine-rich repeats and immunoglobulin-like domains protein 3

(term hierarchy)
PDB

3SO5
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q6P1C6 7 sites, 1 N-linked glycan (1 site)

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All nucleic 43

cDNA 40

Primer pair 3

Microarray probesets 4

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MGI:1914812, MGI:1926172

Summaries

All 49

Developmental Gene Expression 14

Gene Ontology 3

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrig3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96093	Chr10:125802058-125802076 (+)	-21 bp
Tssr96094	Chr10:125802083-125802141 (+)	24 bp
Tssr96095	Chr10:125808249-125808254 (+)	6,164 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24