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Pde8b Gene Detail
Summary
  • Symbol
    Pde8b
  • Name
    phosphodiesterase 8B
  • Synonyms
    B230331L10Rik, C030047E14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443999
    NCBI Gene: 218461
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95160962-95386844 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 49.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6480 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443999
 protein coding gene Chr13:95160962-95386904 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020837
 protein coding gene Chr13:96468898-96704109 (-)
A/J MGP_AJ_G0020791
 protein coding gene Chr13:92853468-93078553 (-)
AKR/J MGP_AKRJ_G0020765
 protein coding gene Chr13:95690163-95917991 (-)
BALB/cJ MGP_BALBcJ_G0020788
 protein coding gene Chr13:93533821-93761575 (-)
C3H/HeJ MGP_C3HHeJ_G0020581
 protein coding gene Chr13:95385396-95623965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021224
 protein coding gene Chr13:99397280-99640115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018793
 protein coding gene Chr13:88690280-88915267 (-)
CAST/EiJ MGP_CASTEiJ_G0020100
 protein coding gene Chr13:94661250-94913323 (-)
CBA/J MGP_CBAJ_G0020540
 protein coding gene Chr13:103347673-103602816 (-)
DBA/2J MGP_DBA2J_G0020665
 protein coding gene Chr13:92639210-92866418 (-)
FVB/NJ MGP_FVBNJ_G0020646
 protein coding gene Chr13:91425944-91650867 (-)
LP/J MGP_LPJ_G0020740
 protein coding gene Chr13:96573579-96825733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020674
 protein coding gene Chr13:103796792-104053358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021264
 protein coding gene Chr13:95090405-95323241 (-)
PWK/PhJ MGP_PWKPhJ_G0019852
 protein coding gene Chr13:91369776-91618048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019676
 protein coding gene Chr13:91373189-91610106 (-)
WSB/EiJ MGP_WSBEiJ_G0020157
 protein coding gene Chr13:95587357-95824238 (-)



Homology
more
  • Human Ortholog
    PDE8B, phosphodiesterase 8B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE8B, phosphodiesterase 8B
  • Synonyms
    ADSD, PPNAD3
  • Links
    NCBI Gene ID: 8622
    neXtProt AC: NX_O95263
    UniProt: O95263

  • Chr Location
    5q13.3; chr5:77086715-77428256 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE8B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    163
  • cDNA Data
    33
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021684 Ensembl Gene Model | MGI Sequence Detail 225883 C57BL/6J ±  kb
    transcript ENSMUST00000067082 Ensembl | MGI Sequence Detail 2598 Not Applicable  
    polypeptide ENSMUSP00000070465 Ensembl | MGI Sequence Detail 865 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8
      IPR011006 CheY-like superfamily
      IPR003607 HD/PDEase domain
      IPR000014 PAS domain
      IPR035965 PAS domain superfamily
    • GlyGen
      E9Q4S1 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924861
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:302971 Leal LF, et al., Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation. Mol Cell Endocrinol. 2021 Feb 15;522:111117
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory