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Srcap Gene Detail
Summary
  • Symbol
    Srcap
  • Name
    Snf2-related CREBBP activator protein
  • Synonyms
    B930091H02Rik, D030022P06Rik, F630004O05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444036
    NCBI Gene: 100043597
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127111155-127160391 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    662 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444036
 protein coding gene Chr7:127111155-127160391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033041
 protein coding gene Chr7:131864525-131920187 (+)
A/J MGP_AJ_G0033024
 protein coding gene Chr7:128363640-128413267 (+)
AKR/J MGP_AKRJ_G0032956
 protein coding gene Chr7:131665279-131718161 (+)
BALB/cJ MGP_BALBcJ_G0033025
 protein coding gene Chr7:128009956-128059744 (+)
C3H/HeJ MGP_C3HHeJ_G0032739
 protein coding gene Chr7:131568993-131620035 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033534
 protein coding gene Chr7:137010852-137062962 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030507
 protein coding gene Chr7:129554079-129601024 (+)
CAST/EiJ MGP_CASTEiJ_G0032068
 protein coding gene Chr7:123363455-123415996 (+)
CBA/J MGP_CBAJ_G0032712
 protein coding gene Chr7:141636207-141691243 (+)
DBA/2J MGP_DBA2J_G0032864
 protein coding gene Chr7:126336991-126387046 (+)
FVB/NJ MGP_FVBNJ_G0032817
 protein coding gene Chr7:126182715-126232704 (+)
LP/J MGP_LPJ_G0032958
 protein coding gene Chr7:133347505-133398643 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032849
 protein coding gene Chr7:142750240-142809279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033554
 protein coding gene Chr7:130655070-130713738 (+)
PWK/PhJ MGP_PWKPhJ_G0031775
 protein coding gene Chr7:119345713-119396263 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031621
 protein coding gene Chr7:117471115-117521924 (+)
WSB/EiJ MGP_WSBEiJ_G0032180
 protein coding gene Chr7:131629326-131680467 (+)



Homology
more
  • Human Ortholog
    SRCAP, Snf2 related CREBBP activator protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRCAP, Snf2 related CREBBP activator protein
  • Synonyms
    DEHMBA, DOMO1, EAF1, FLHS, SWR1
  • Links
    NCBI Gene ID: 10847
    neXtProt AC: NX_Q6ZRS2
    UniProt: Q6ZRS2

  • Chr Location
    16p11.2; chr16:30698209-30741409 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SRCAP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show impaired blastocyst development at E3.5 and early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    10
  • cDNA Data
    25
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100043597 NCBI Gene Model | MGI Sequence Detail 49237 C57BL/6J ±  kb
transcript NM_001304266 RefSeq | MGI Sequence Detail 10914 C57BL/6  
polypeptide NP_001291195 RefSeq | MGI Sequence Detail 3271 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • InterPro Domains
    IPR017956 AT hook, DNA-binding motif
    IPR001650 Helicase, C-terminal domain-like
    IPR014012 Helicase/SANT-associated domain
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR050520 INO80/SWR1 chromatin remodeling helicase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR038718 SNF2-like, N-terminal domain superfamily
    IPR000330 SNF2, N-terminal
    IPR049730 SNF2/RAD5-like, C-terminal helicase domain
Molecular
Reagents
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  • All nucleic 29
    Genomic 1
    cDNA 26
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:2445189, MGI:3603830
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:349846 Ding C, et al., Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression. Cell Rep. 2024 May 28;43(5):114231
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory