Atp13a5 MGI Mouse Gene Detail - MGI:2444068

Symbol

Atp13a5
Name

ATPase type 13A5
Synonyms

C630015F21Rik

Feature Type

protein coding gene
IDs

MGI:2444068
NCBI Gene: 268878
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:29050603-29197550 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 20.03 cM
Mapping Data

2 experiments

SNPs within 2kb

4129 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444068	protein coding gene	Chr16:29049242-29208807 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022704	protein coding gene	Chr16:27066019-27221758 (-)
A/J	MGP_AJ_G0022667	protein coding gene	Chr16:25826584-25968909 (-)
AKR/J	MGP_AKRJ_G0022641	protein coding gene	Chr16:26800865-26952824 (-)
BALB/cJ	MGP_BALBcJ_G0022671	protein coding gene	Chr16:26009587-26154329 (-)
C3H/HeJ	MGP_C3HHeJ_G0022436	protein coding gene	Chr16:26909938-27058757 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023120	protein coding gene	Chr16:27635572-27785829 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020638	protein coding gene	Chr16:26295476-26430463 (-)
CAST/EiJ	MGP_CASTEiJ_G0021964	protein coding gene	Chr16:26982486-27132144 (-)
CBA/J	MGP_CBAJ_G0022406	protein coding gene	Chr16:28817580-28977016 (-)
DBA/2J	MGP_DBA2J_G0022539	protein coding gene	Chr16:25714017-25856221 (-)
FVB/NJ	MGP_FVBNJ_G0022514	protein coding gene	Chr16:25687865-25835321 (-)
LP/J	MGP_LPJ_G0022606	protein coding gene	Chr16:26864752-27022991 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022533	protein coding gene	Chr16:28409243-28559507 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023132	protein coding gene	Chr16:26752541-26901543 (-)
PWK/PhJ	MGP_PWKPhJ_G0021703	protein coding gene	Chr16:26010101-26149909 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021534	protein coding gene	Chr16:26521069-26658281 (-)
WSB/EiJ	MGP_WSBEiJ_G0022008	protein coding gene	Chr16:26693616-26839126 (-)

Human Ortholog

ATP13A5, ATPase 13A5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP13A5, ATPase 13A5
Links

HGNC:31789

NCBI Gene ID: 344905

neXtProt AC: NX_Q4VNC0

UniProt: Q4VNC0
Chr Location

3q29; chr3:193274789-193378820 (-) GRCh38

MGI Vertebrate Homology

Atp13a5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ATP13A5
Gene Tree

Atp13a5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available

Homozygous mutant mice show a decreased mean percentage of natural killer cells when compared with controls. Male homozygous mutant mice exhibit impaired sensorimotor gating/attention during prepulse inhibition testing.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

99
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

8
UniProt

4
CCDS

CCDS28095.1, CCDS70705.1

Ensembl

ENSMUSG00000048939 (Evidence)
NCBI Gene

268878

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048939	Ensembl Gene Model \| MGI Sequence Detail	146948	C57BL/6J	± kb
transcript	ENSMUST00000075806	Ensembl \| MGI Sequence Detail	4598	Not Applicable
polypeptide	ENSMUSP00000075204	Ensembl \| MGI Sequence Detail	1216	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032195 probable cation-transporting ATPase 13A5

(term hierarchy)
EC

7.2.2.-
InterPro Domains

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR047821 P5B-type ATPase

IPR047819 P5B-type ATPase, N-terminal

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR018303 P-type ATPase, phosphorylation site

IPR006544 P-type ATPase, subfamily V

IPR023298 P-type ATPase, transmembrane domain superfamily
GlyGen

Q3TYU2 5 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:357894 Guo X, et al., Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System. J Neurosci. 2024 Oct 23;44(43)

TSS for Atp13a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140680	Chr16:29197514-29197530 (-)	28 bp
Tssr140679	Chr16:29197430-29197443 (-)	113 bp
Tssr140678	Chr16:29197388-29197428 (-)	142 bp
Tssr140677	Chr16:29051788-29051792 (-)	145,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24