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Tanc2 Gene Detail
Summary
  • Symbol
    Tanc2
  • Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  • Synonyms
    3526402J09Rik, 5730590C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444121
    NCBI Gene: 77097
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105480812-105820130 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5936 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444121
 protein coding gene Chr11:105480458-105820130 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019286
 protein coding gene Chr11:108828527-109191386 (+)
A/J MGP_AJ_G0019254
 protein coding gene Chr11:104189395-104548908 (+)
AKR/J MGP_AKRJ_G0019223
 protein coding gene Chr11:107329177-107667703 (+)
BALB/cJ MGP_BALBcJ_G0019228
 protein coding gene Chr11:104609520-104953454 (+)
C3H/HeJ MGP_C3HHeJ_G0019037
 protein coding gene Chr11:107618871-107965836 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019678
 protein coding gene Chr11:112201300-112548533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017303
 protein coding gene Chr11:101524713-101840855 (+)
CAST/EiJ MGP_CASTEiJ_G0018590
 protein coding gene Chr11:108671250-109013990 (+)
CBA/J MGP_CBAJ_G0019006
 protein coding gene Chr11:116851314-117228504 (+)
DBA/2J MGP_DBA2J_G0019118
 protein coding gene Chr11:103677514-104017960 (+)
FVB/NJ MGP_FVBNJ_G0019109
 protein coding gene Chr11:103194926-103527271 (+)
LP/J MGP_LPJ_G0019188
 protein coding gene Chr11:109293501-109645307 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019139
 protein coding gene Chr11:116113105-116519524 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019715
 protein coding gene Chr11:107805124-108156271 (+)
PWK/PhJ MGP_PWKPhJ_G0018355
 protein coding gene Chr11:104779996-105115112 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018146
 protein coding gene Chr11:107566738-107919980 (+)
WSB/EiJ MGP_WSBEiJ_G0018641
 protein coding gene Chr11:107776998-108124695 (+)



Homology
more
  • Human Ortholog
    TANC2, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TANC2, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  • Synonyms
    IDDALDS, rols, ROLSA
  • Links
    NCBI Gene ID: 26115
    neXtProt AC: NX_Q9HCD6
    UniProt: Q9HCD6

  • Chr Location
    17q23.2-q23.3; chr17:62966235-63427703 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TANC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap vector die prior to E12.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    115
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053580 Ensembl Gene Model | MGI Sequence Detail 339319 C57BL/6J ±  kb
    transcript ENSMUST00000100330 Ensembl | MGI Sequence Detail 11855 Not Applicable  
    polypeptide ENSMUSP00000097904 Ensembl | MGI Sequence Detail 1994 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000016047 protein TANC2
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR050889 Dendritic Spine Regulation and Scaffold
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      A2A690 8 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 115
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924347
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory