About   Help   FAQ
Rasal3 Gene Detail
Summary
  • Symbol
    Rasal3
  • Name
    RAS protein activator like 3
  • Synonyms
    A430107D22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444128
    NCBI Gene: 320484
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32609633-32622557 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.55 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444128
 protein coding gene Chr17:32609633-32622586 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023504
 protein coding gene Chr17:32231138-32244110 (-)
A/J MGP_AJ_G0023461
 protein coding gene Chr17:31158314-31171380 (-)
AKR/J MGP_AKRJ_G0023427
 protein coding gene Chr17:31441715-31458035 (-)
BALB/cJ MGP_BALBcJ_G0023466
 protein coding gene Chr17:31251480-31264454 (-)
C3H/HeJ MGP_C3HHeJ_G0023228
 protein coding gene Chr17:31842088-31855070 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023909
 protein coding gene Chr17:33321669-33334619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021383
 protein coding gene Chr17:28261081-28274156 (-)
CAST/EiJ MGP_CASTEiJ_G0022729
 protein coding gene Chr17:31895244-31908162 (-)
CBA/J MGP_CBAJ_G0023203
 protein coding gene Chr17:34785412-34798391 (-)
DBA/2J MGP_DBA2J_G0023333
 protein coding gene Chr17:30534864-30547596 (-)
FVB/NJ MGP_FVBNJ_G0023303
 protein coding gene Chr17:30360746-30373674 (-)
LP/J MGP_LPJ_G0023411
 protein coding gene Chr17:32446017-32458911 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023321
 protein coding gene Chr17:33843069-33861559 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023951
 protein coding gene Chr17:31805403-31819658 (-)
PWK/PhJ MGP_PWKPhJ_G0022478
 protein coding gene Chr17:29427594-29442003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022297
 protein coding gene Chr17:29823569-29839992 (-)
WSB/EiJ MGP_WSBEiJ_G0022791
 protein coding gene Chr17:31787352-31801829 (-)



Homology
more
  • Human Ortholog
    RASAL3, RAS protein activator like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASAL3, RAS protein activator like 3
  • Links
    NCBI Gene ID: 64926
    neXtProt AC: NX_Q86YV0
    UniProt: Q86YV0

  • Chr Location
    19p13.12; chr19:15451624-15464544 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced NT T cells in the liver, increased granulocytes in the bone marrow and decreased susceptibility to alpha-GalCer-induced liver injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052142 Ensembl Gene Model | MGI Sequence Detail 12925 C57BL/6J ±  kb
    transcript ENSMUST00000137458 Ensembl | MGI Sequence Detail 3272 Not Applicable  
    polypeptide ENSMUSP00000123141 Ensembl | MGI Sequence Detail 1043 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:346014 Olivier JF, et al., CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Commun Biol. 2024 Jan 10;7(1):77
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory