Mars2 MGI Mouse Gene Detail - MGI:2444136 - methionine-tRNA synthetase 2 (mitochondrial)

Symbol

Mars2
Name

methionine-tRNA synthetase 2 (mitochondrial)
Synonyms

C730026E21Rik

Feature Type

protein coding gene
IDs

MGI:2444136
NCBI Gene: 212679
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:55276336-55279217 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 28.08 cM
Mapping Data

2 experiments

SNPs within 2kb

113 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444136	protein coding gene	Chr1:55276336-55287629 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016034	protein coding gene	Chr1:54971484-54982777 (+)
A/J	MGP_AJ_G0016017	protein coding gene	Chr1:53052961-53064258 (+)
AKR/J	MGP_AKRJ_G0015973	protein coding gene	Chr1:54493828-54505123 (+)
BALB/cJ	MGP_BALBcJ_G0015972	protein coding gene	Chr1:53100820-53112115 (+)
C3H/HeJ	MGP_C3HHeJ_G0015804	protein coding gene	Chr1:54737057-54748354 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016425	protein coding gene	Chr1:57239719-57251012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014147	protein coding gene	Chr1:49140390-49151659 (+)
CAST/EiJ	MGP_CASTEiJ_G0015386	protein coding gene	Chr1:54021391-54033578 (+)
CBA/J	MGP_CBAJ_G0015776	protein coding gene	Chr1:58871824-58883121 (+)
DBA/2J	MGP_DBA2J_G0015877	protein coding gene	Chr1:52474390-52485687 (+)
FVB/NJ	MGP_FVBNJ_G0015879	protein coding gene	Chr1:51819619-51830916 (+)
LP/J	MGP_LPJ_G0015949	protein coding gene	Chr1:55794788-55806081 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015899	protein coding gene	Chr1:61961308-61972607 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016472	protein coding gene	Chr1:54442307-54453606 (+)
PWK/PhJ	MGP_PWKPhJ_G0015172	protein coding gene	Chr1:51837264-51848791 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014953	protein coding gene	Chr1:54073198-54086237 (+)
WSB/EiJ	MGP_WSBEiJ_G0015449	protein coding gene	Chr1:54129421-54140720 (+)

Human Ortholog

MARS2, methionyl-tRNA synthetase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARS2, methionyl-tRNA synthetase 2, mitochondrial
Synonyms

COXPD25, MetRS, mtMetRS
Links

HGNC:25133

NCBI Gene ID: 92935

neXtProt AC: NX_Q96GW9

UniProt: Q96GW9
Chr Location

2q33.1; chr2:197705369-197708395 (+) GRCh38

MGI Vertebrate Homology

Mars2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARS2
Gene Tree

Mars2

Diseases

2 with human MARS2 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 25 IDs combined oxidative phosphorylation deficiency 25 DOID:0111468 OMIM:616430 ORDO:447954
				spastic ataxia 3 IDs spastic ataxia 3 DOID:0050942 OMIM:611390

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 2 genetic backgrounds
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mars2
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.

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All GO Annotations

12
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

146
cDNA Data

25
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS14963.1

Ensembl

ENSMUSG00000046994 (Evidence)
NCBI Gene

212679

			Length	Strain/Species	Flank
genomic	212679	NCBI Gene Model \| MGI Sequence Detail	2882	C57BL/6J	± kb
transcript	NM_175439	RefSeq \| MGI Sequence Detail	2882	Not Specified
polypeptide	Q499X9	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010191 methionyl-tRNA synthetase, mitochondrial

(term hierarchy)
EC

6.1.1.10
InterPro Domains

IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

IPR023457 Methionine-tRNA synthetase, type 2

IPR033911 Methioninyl-tRNA synthetase core domain

IPR015413 Methionyl/Leucyl tRNA synthetase

IPR014758 Methionyl-tRNA synthetase

IPR041872 Methionyl-tRNA synthetase, anticodon-binding domain

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

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All nucleic 27

cDNA 25

Primer pair 2

Microarray probesets 5

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mars2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6721	Chr1:55276350-55276414 (+)	46 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24