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Ipcef1 Gene Detail
Summary
  • Symbol
    Ipcef1
  • Name
    interaction protein for cytohesin exchange factors 1
  • Synonyms
    A130090K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444159
    NCBI Gene: 320495
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:6835779-6973185 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 1.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4723 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444159
 protein coding gene Chr10:6835779-7002478 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016991
 protein coding gene Chr10:4011778-4207789 (-)
A/J MGP_AJ_G0016969
 protein coding gene Chr10:3837587-4016918 (-)
AKR/J MGP_AKRJ_G0016934
 protein coding gene Chr10:3884580-4077319 (-)
BALB/cJ MGP_BALBcJ_G0016927
 protein coding gene Chr10:3791057-3957242 (-)
C3H/HeJ MGP_C3HHeJ_G0016752
 protein coding gene Chr10:4036279-4213690 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017390
 protein coding gene Chr10:4176173-4350620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015095
 protein coding gene Chr10:3483761-3640144 (-)
CAST/EiJ MGP_CASTEiJ_G0016334
 protein coding gene Chr10:4004902-4177751 (-)
CBA/J MGP_CBAJ_G0016724
 protein coding gene Chr10:4321543-4511451 (-)
DBA/2J MGP_DBA2J_G0016832
 protein coding gene Chr10:3795156-3928420 (-)
FVB/NJ MGP_FVBNJ_G0016827
 protein coding gene Chr10:3711843-3875632 (-)
LP/J MGP_LPJ_G0016907
 protein coding gene Chr10:3900069-4072081 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016857
 protein coding gene Chr10:4175770-4372639 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017427
 protein coding gene Chr10:3883785-4044878 (-)
PWK/PhJ MGP_PWKPhJ_G0016120
 protein coding gene Chr10:3768217-3937171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015901
 protein coding gene Chr10:4075631-4269021 (-)
WSB/EiJ MGP_WSBEiJ_G0016396
 protein coding gene Chr10:3955209-4095641 (-)



Homology
more
  • Human Ortholog
    IPCEF1, interaction protein for cytohesin exchange factors 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IPCEF1, interaction protein for cytohesin exchange factors 1
  • Synonyms
    PIP3-E, PIP3E
  • Links
    NCBI Gene ID: 26034
    neXtProt AC: NX_Q8WWN9
    UniProt: Q8WWN9

  • Chr Location
    6q25.2; chr6:154154496-154356803 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320495 NCBI Gene Model | MGI Sequence Detail 137407 C57BL/6J ±  kb
transcript NM_001347225 RefSeq | MGI Sequence Detail 5968 C57BL/6  
polypeptide Q5DU31 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009083 interactor protein for cytohesin exchange factors 1
    (term hierarchy)
  • InterPro Domains
    IPR051566 Connector enhancer of kinase suppressor of Ras
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
  • GlyGen
    Q5DU31 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 5
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:334250 Marks KE, et al., Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration. Cell Rep. 2021 Jun 29;35(13):109303
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory