Ccar2 MGI Mouse Gene Detail - MGI:2444228 - cell cycle activator and apoptosis regulator 2

Symbol

Ccar2
Name

cell cycle activator and apoptosis regulator 2
Synonyms

2610301G19Rik, Dbc1, mKIAA1967

Feature Type

protein coding gene
IDs

MGI:2444228
NCBI Gene: 219158
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:70375613-70391260 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.24 cM
Mapping Data

1 experiment

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444228	protein coding gene	Chr14:70375613-70391272 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021530	protein coding gene	Chr14:64759342-64775007 (-)
A/J	MGP_AJ_G0021489	protein coding gene	Chr14:63401426-63417055 (-)
AKR/J	MGP_AKRJ_G0021465	protein coding gene	Chr14:65301222-65316856 (-)
BALB/cJ	MGP_BALBcJ_G0021495	protein coding gene	Chr14:63161627-63177261 (-)
C3H/HeJ	MGP_C3HHeJ_G0021272	protein coding gene	Chr14:65013894-65029528 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021934	protein coding gene	Chr14:67676019-67693090 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019474	protein coding gene	Chr14:61238765-61254296 (-)
CAST/EiJ	MGP_CASTEiJ_G0020789	protein coding gene	Chr14:61598026-61613686 (-)
CBA/J	MGP_CBAJ_G0021239	protein coding gene	Chr14:69790696-69806330 (-)
DBA/2J	MGP_DBA2J_G0021362	protein coding gene	Chr14:62782862-62798690 (-)
FVB/NJ	MGP_FVBNJ_G0021341	protein coding gene	Chr14:62211275-62226909 (-)
LP/J	MGP_LPJ_G0021433	protein coding gene	Chr14:66012313-66027981 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021370	protein coding gene	Chr14:68706158-68721826 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021958	protein coding gene	Chr14:64565174-64580803 (-)
PWK/PhJ	MGP_PWKPhJ_G0020533	protein coding gene	Chr14:59544799-59560700 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020366	protein coding gene	Chr14:60488063-60505023 (-)
WSB/EiJ	MGP_WSBEiJ_G0020842	protein coding gene	Chr14:64870388-64886896 (-)

Human Ortholog

CCAR2, cell cycle and apoptosis regulator 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCAR2, cell cycle and apoptosis regulator 2
Synonyms

DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
Links

HGNC:23360

NCBI Gene ID: 57805

neXtProt AC: NX_Q8N163

UniProt: Q8N163
Chr Location

8p21.3; chr8:22604757-22621514 (+) GRCh38

MGI Vertebrate Homology

Ccar2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCAR2
Gene Tree

Ccar2

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

3
Targeted

2
Genomic Mutations

1 involving Ccar2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice on a high fat diet are resistant to hepatic steatosis and associated liver inflammation.

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All GO Annotations

57
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

9
cDNA Data

71
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

7
UniProt

1
CCDS

CCDS49534.1

Ensembl

ENSMUSG00000033712 (Evidence)
NCBI Gene

219158

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033712	Ensembl Gene Model \| MGI Sequence Detail	15648	C57BL/6J	± kb
transcript	ENSMUST00000035612	Ensembl \| MGI Sequence Detail	3725	Not Applicable
polypeptide	ENSMUSP00000036924	Ensembl \| MGI Sequence Detail	922	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000039818 cell cycle and apoptosis regulator protein 2

(term hierarchy)
InterPro Domains

IPR045354 BURAN domain

IPR025224 Cell cycle and apoptosis regulator protein

IPR025954 DBC1/CARP1 catalytically inactive NUDIX hydrolase domain

IPR011992 EF-hand domain pair

IPR045353 LAIKA domain

IPR025223 S1-like RNA binding domain
GlyGen

Q8VDP4 1 site, 1 O-linked glycan (1 site)

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All nucleic 72

cDNA 72

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ccar2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129519	Chr14:70391266-70391295 (-)	-21 bp
Tssr129518	Chr14:70391134-70391182 (-)	102 bp
Tssr129517	Chr14:70391100-70391127 (-)	146 bp
Tssr129516	Chr14:70390834-70390913 (-)	386 bp
Tssr129515	Chr14:70390652-70390655 (-)	606 bp
Tssr129514	Chr14:70390196-70390206 (-)	1,059 bp
Tssr129513	Chr14:70389880-70389911 (-)	1,364 bp
Tssr129512	Chr14:70388746-70388790 (-)	2,492 bp
Tssr4468	Chr14:70383414-70383415 (-)	7,845 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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