Ythdf2 MGI Mouse Gene Detail - MGI:2444233 - YTH N6-methyladenosine RNA binding protein 2

Symbol

Ythdf2
Name

YTH N6-methyladenosine RNA binding protein 2
Synonyms

9430020E02Rik, HGRG8, NY-REN-2

Feature Type

protein coding gene
IDs

MGI:2444233
NCBI Gene: 213541
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:131912227-131939567 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 64.92 cM
Mapping Data

1 experiment

SNPs within 2kb

628 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444233	protein coding gene	Chr4:131912223-131939614 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028864	protein coding gene	Chr4:134318717-134347065 (-)
A/J	MGP_AJ_G0028823	protein coding gene	Chr4:128736634-128765077 (-)
AKR/J	MGP_AKRJ_G0028776	protein coding gene	Chr4:132347984-132380223 (-)
BALB/cJ	MGP_BALBcJ_G0028846	protein coding gene	Chr4:129346808-129374434 (-)
C3H/HeJ	MGP_C3HHeJ_G0028560	protein coding gene	Chr4:132598812-132627124 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029288	protein coding gene	Chr4:139150168-139184026 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026560	protein coding gene	Chr4:121842045-121850148 (-)
CAST/EiJ	MGP_CASTEiJ_G0027993	protein coding gene	Chr4:130670342-130700335 (-)
CBA/J	MGP_CBAJ_G0028526	protein coding gene	Chr4:142714575-142753206 (-)
DBA/2J	MGP_DBA2J_G0028675	protein coding gene	Chr4:129161182-129189152 (-)
FVB/NJ	MGP_FVBNJ_G0028642	protein coding gene	Chr4:128010934-128037853 (-)
LP/J	MGP_LPJ_G0028776	protein coding gene	Chr4:134471439-134498544 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028668	protein coding gene	Chr4:147325233-147352799 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029326	protein coding gene	Chr4:132753182-132780958 (-)
PWK/PhJ	MGP_PWKPhJ_G0027714	protein coding gene	Chr4:125836064-125864580 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027540	protein coding gene	Chr4:128624561-128654162 (-)
WSB/EiJ	MGP_WSBEiJ_G0028073	protein coding gene	Chr4:132946000-132957781 (-)

Human Ortholog

YTHDF2, YTH N6-methyladenosine RNA binding protein F2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YTHDF2, YTH N6-methyladenosine RNA binding protein F2
Synonyms

CAHL, DF2, HGRG8, NY-REN-2
Links

HGNC:31675

NCBI Gene ID: 51441

neXtProt AC: NX_Q9Y5A9

UniProt: Q9Y5A9
Chr Location

1p35.3; chr1:28736621-28769775 (+) GRCh38

MGI Vertebrate Homology

Ythdf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YTHDF2
Gene Tree

Ythdf2

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Phenotype Summary

9 phenotypes from 3 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Chemically induced (other)

2
Endonuclease-mediated

11
Gene trapped

68
Radiation induced

1
Targeted

8
Genomic Mutations

4 involving Ythdf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozgyous for a knock-out allele exhibit female, but not male, infertility and preweaning lethality that is background sensitive. Homozygous KO male mice are hypo-fertile.

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All GO Annotations

58
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ythdf2

ZFIN ythdf2

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All Sequences

52
RefSeq

2
UniProt

5
CCDS

CCDS18719.1

Ensembl

ENSMUSG00000040025 (Evidence)
NCBI Gene

213541

			Length	Strain/Species	Flank
genomic	213541	NCBI Gene Model \| MGI Sequence Detail	27341	C57BL/6J	± kb
transcript	NM_145393	RefSeq \| MGI Sequence Detail	4078	C57BL/6
polypeptide	Q91YT7	UniProt \| EBI \| MGI Sequence Detail	579	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029877 YTH domain-containing family protein 2

(term hierarchy)
InterPro Domains

IPR007275 YTH domain

IPR045168 YTH domain containing protein
GlyGen

Q91YT7 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 4

Summaries

All 68

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 36
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:358948 Zhang F, et al., m(6)A/YTHDF2-mediated mRNA decay targets TGF-beta signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs. Cell Stem Cell. 2024 Oct 22;

TSS for Ythdf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43648	Chr4:131939566-131939573 (-)	-3 bp
Tssr43647	Chr4:131939452-131939464 (-)	109 bp
Tssr43646	Chr4:131939371-131939441 (-)	161 bp
Tssr43645	Chr4:131939352-131939370 (-)	206 bp
Tssr43644	Chr4:131939310-131939321 (-)	251 bp
Tssr43643	Chr4:131933750-131933754 (-)	5,815 bp
Tssr43642	Chr4:131919589-131919592 (-)	19,976 bp
Tssr43641	Chr4:131913893-131913913 (-)	25,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24