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Cfap65 Gene Detail
Summary
  • Symbol
    Cfap65
  • Name
    cilia and flagella associated protein 65
  • Synonyms
    B230363K08Rik, Ccdc108
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444274
    NCBI Gene: 241116
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74941230-74974758 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    777 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444274
 protein coding gene Chr1:74941230-74974785 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016167
 protein coding gene Chr1:75515444-75552088 (-)
A/J MGP_AJ_G0016150
 protein coding gene Chr1:72885883-72919407 (-)
AKR/J MGP_AKRJ_G0016107
 protein coding gene Chr1:74901077-74934408 (-)
BALB/cJ MGP_BALBcJ_G0016105
 protein coding gene Chr1:72946324-72980515 (-)
C3H/HeJ MGP_C3HHeJ_G0015936
 protein coding gene Chr1:75245177-75278579 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016558
 protein coding gene Chr1:78459809-78494010 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014279
 protein coding gene Chr1:68448036-68482392 (-)
CAST/EiJ MGP_CASTEiJ_G0015520
 protein coding gene Chr1:74570511-74607717 (-)
CBA/J MGP_CBAJ_G0015909
 protein coding gene Chr1:81016932-81052678 (-)
DBA/2J MGP_DBA2J_G0016010
 protein coding gene Chr1:72202693-72236878 (-)
FVB/NJ MGP_FVBNJ_G0016013
 protein coding gene Chr1:71401267-71434423 (-)
LP/J MGP_LPJ_G0016082
 protein coding gene Chr1:76637411-76671857 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016033
 protein coding gene Chr1:84392196-84425534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016605
 protein coding gene Chr1:74974673-75009124 (-)
PWK/PhJ MGP_PWKPhJ_G0015307
 protein coding gene Chr1:71666866-71700639 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015085
 protein coding gene Chr1:74340618-74376740 (-)
WSB/EiJ MGP_WSBEiJ_G0015582
 protein coding gene Chr1:74793533-74826920 (-)



Homology
more
  • Human Ortholog
    CFAP65, cilia and flagella associated protein 65
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP65, cilia and flagella associated protein 65
  • Synonyms
    CCDC108, SPGF40
  • Links
    NCBI Gene ID: 255101
    neXtProt AC: NX_Q6ZU64
    UniProt: Q6ZU64

  • Chr Location
    2q35; chr2:219002846-219041551 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cfap65 mouse models; 1 with human CFAP65 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a frameshift mutation display male sterility with multiple sperm flagella malformations and asthenospermia. Males homozygous for a knock-out allele are sterile and show severe oligoasthenoteratospermia with defects in sperm head shaping, acrosome formation and flagellar assembly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047021 Ensembl Gene Model | MGI Sequence Detail 33529 C57BL/6J ±  kb
    transcript ENSMUST00000094844 Ensembl | MGI Sequence Detail 5727 Not Applicable  
    polypeptide ENSMUSP00000092440 Ensembl | MGI Sequence Detail 1847 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000032830 cilia- and flagella-associated protein 65
      (term hierarchy)
    • InterPro Domains
      IPR031549 Abnormal spindle-like microcephaly-associated protein, ASH domain
      IPR052614 Cilia-Flagella-Associated Protein 65
      IPR013783 Immunoglobulin-like fold
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 7
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory