Arid4a MGI Mouse Gene Detail - MGI:2444354 - AT-rich interaction domain 4A

Symbol

Arid4a
Name

AT-rich interaction domain 4A
Synonyms

A630067N03Rik, Rbbp1

Feature Type

protein coding gene
IDs

MGI:2444354
NCBI Gene: 238247
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr12:71062764-71145366 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 29.39 cM
Mapping Data

2 experiments

SNPs within 2kb

1943 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444354	protein coding gene	Chr12:71061314-71146125 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019814	protein coding gene	Chr12:70801375-70877579 (+)
A/J	MGP_AJ_G0019772	protein coding gene	Chr12:68156235-68228113 (+)
AKR/J	MGP_AKRJ_G0019748	protein coding gene	Chr12:70194132-70270960 (+)
BALB/cJ	MGP_BALBcJ_G0019752	protein coding gene	Chr12:68627558-68698104 (+)
C3H/HeJ	MGP_C3HHeJ_G0019557	protein coding gene	Chr12:70674555-70752937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020204	protein coding gene	Chr12:73048242-73131511 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017824	protein coding gene	Chr12:65657532-65724882 (+)
CAST/EiJ	MGP_CASTEiJ_G0019109	protein coding gene	Chr12:65416341-65491307 (+)
CBA/J	MGP_CBAJ_G0019527	protein coding gene	Chr12:75762013-75852678 (+)
DBA/2J	MGP_DBA2J_G0019643	protein coding gene	Chr12:68059582-68138501 (+)
FVB/NJ	MGP_FVBNJ_G0019630	protein coding gene	Chr12:66948444-67018207 (+)
LP/J	MGP_LPJ_G0019715	protein coding gene	Chr12:70777233-70863398 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019669	protein coding gene	Chr12:79010072-79085443 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020239	protein coding gene	Chr12:69696222-69764097 (+)
PWK/PhJ	MGP_PWKPhJ_G0018874	protein coding gene	Chr12:62337430-62412377 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018669	protein coding gene	Chr12:64055693-64126902 (+)
WSB/EiJ	MGP_WSBEiJ_G0019160	protein coding gene	Chr12:70301691-70374138 (+)

Human Ortholog

ARID4A, AT-rich interaction domain 4A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARID4A, AT-rich interaction domain 4A
Synonyms

RBBP-1, RBBP1, RBP-1, RBP1
Links

HGNC:9885

NCBI Gene ID: 5926

neXtProt AC: NX_P29374

UniProt: P29374
Chr Location

14q23.1; chr14:58298504-58373887 (+) GRCh38

MGI Vertebrate Homology

Arid4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARID4A
Gene Tree

Arid4a

Diseases

1 with Arid4a mouse models

Human Disease

Mouse Models

acute myeloid leukemia

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

36 phenotypes from 4 alleles in 5 genetic backgrounds
33 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (ENU)

2
Chemically induced (other)

1
Gene trapped

23
Targeted

3
Genomic Mutations

1 involving Arid4a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered DNA methylation patterns, disrupted hematopoiesis and a portion develop acute myeloid leukemia. Mice homozygous for an ENU-induced allele exhibit short tibia and femur.

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All GO Annotations

28
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

15
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arid4a

ZFIN arid4a

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All Sequences

65
RefSeq

15
UniProt

6
CCDS

CCDS36471.1

Ensembl

ENSMUSG00000048118 (Evidence)
NCBI Gene

238247

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048118	Ensembl Gene Model \| MGI Sequence Detail	82603	C57BL/6J	± kb
transcript	ENSMUST00000046305	Ensembl \| MGI Sequence Detail	4998	Not Applicable
polypeptide	ENSMUSP00000035512	Ensembl \| MGI Sequence Detail	1261	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004267 AT-rich interactive domain-containing protein 4A

(term hierarchy)
InterPro Domains

IPR012603 ARID4A/B, PWWP domain

IPR047473 ARID4A, chromo barrel domain

IPR047472 ARID4A, first Tudor domain

IPR001606 ARID DNA-binding domain

IPR036431 ARID DNA-binding domain superfamily

IPR051232 AT-rich Interactive Domain/SWI1 Chromatin Remodeling

IPR000953 Chromo/chromo shadow domain

IPR016197 Chromo-like domain superfamily

IPR025995 RNA binding activity-knot of a chromodomain

IPR002999 Tudor domain

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 5

Summaries

All 51

Developmental Gene Expression 4

Diseases 1

Gene Ontology 11

Phenotypes 18
Earliest

J:320044 Zhang Y, et al., SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arid4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113708	Chr12:71062704-71062724 (+)	-50 bp
Tssr113709	Chr12:71062740-71062837 (+)	25 bp
Tssr113710	Chr12:71063432-71063464 (+)	684 bp
Tssr113711	Chr12:71083739-71083750 (+)	20,981 bp
Tssr113712	Chr12:71095112-71095130 (+)	32,357 bp
Tssr113713	Chr12:71095146-71095193 (+)	32,406 bp
Tssr113714	Chr12:71106156-71106157 (+)	43,393 bp
Tssr113715	Chr12:71109974-71109986 (+)	47,216 bp
Tssr113716	Chr12:71110030-71110053 (+)	47,278 bp
Tssr113717	Chr12:71116763-71116768 (+)	54,002 bp
Tssr113718	Chr12:71121734-71121770 (+)	58,988 bp
Tssr113719	Chr12:71144410-71144424 (+)	81,653 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24