Galnt11 MGI Mouse Gene Detail - MGI:2444392 - polypeptide N-acetylgalactosaminyltransferase 11

Symbol

Galnt11
Name

polypeptide N-acetylgalactosaminyltransferase 11
Synonyms

A430075I06Rik, E430002F06Rik

Feature Type

protein coding gene
IDs

MGI:2444392
NCBI Gene: 231050
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:25427732-25470916 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 12.35 cM
Mapping Data

2 experiments

SNPs within 2kb

1014 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444392	protein coding gene	Chr5:25426902-25470916 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029359	protein coding gene	Chr5:23007066-23043232 (+)
A/J	MGP_AJ_G0029325	protein coding gene	Chr5:22205978-22240064 (+)
AKR/J	MGP_AKRJ_G0029276	protein coding gene	Chr5:23107630-23141619 (+)
BALB/cJ	MGP_BALBcJ_G0029336	protein coding gene	Chr5:22715640-22751126 (+)
C3H/HeJ	MGP_C3HHeJ_G0029056	protein coding gene	Chr5:23208157-23243382 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029789	protein coding gene	Chr5:24532001-24575588 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027027	protein coding gene	Chr5:20124242-20157127 (+)
CAST/EiJ	MGP_CASTEiJ_G0028468	protein coding gene	Chr5:22416851-22456593 (+)
CBA/J	MGP_CBAJ_G0029023	protein coding gene	Chr5:24967519-25001695 (+)
DBA/2J	MGP_DBA2J_G0029174	protein coding gene	Chr5:22481876-22517811 (+)
FVB/NJ	MGP_FVBNJ_G0029132	protein coding gene	Chr5:21864912-21909830 (+)
LP/J	MGP_LPJ_G0029258	protein coding gene	Chr5:23411524-23445814 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029161	protein coding gene	Chr5:26009997-26044550 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029823	protein coding gene	Chr5:22734635-22775942 (+)
PWK/PhJ	MGP_PWKPhJ_G0028192	protein coding gene	Chr5:21589176-21623735 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028023	protein coding gene	Chr5:22094407-22129636 (+)
WSB/EiJ	MGP_WSBEiJ_G0028548	protein coding gene	Chr5:22820557-22855970 (+)

Human Ortholog

GALNT11, polypeptide N-acetylgalactosaminyltransferase 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GALNT11, polypeptide N-acetylgalactosaminyltransferase 11
Synonyms

GALNAC-T11, GALNACT11
Links

HGNC:19875

NCBI Gene ID: 63917

neXtProt AC: NX_Q8NCW6

UniProt: Q8NCW6
Chr Location

7q36.1; chr7:152025674-152122340 (+) GRCh38

MGI Vertebrate Homology

Galnt11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GALNT11
Gene Tree

Galnt11

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

5 involving Galnt11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced viability over time, smaller size, low-molecular-weight proteinuria and increased blood urea nitrogen level.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

103
cDNA Data

16
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase galnt11

ZFIN galnt11

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All Sequences

53
RefSeq

5
UniProt

2
CCDS

CCDS19133.1

Ensembl

ENSMUSG00000038072 (Evidence)
NCBI Gene

231050

			Length	Strain/Species	Flank
genomic	231050	NCBI Gene Model \| MGI Sequence Detail	43185	C57BL/6J	± kb
transcript	NM_144908	RefSeq \| MGI Sequence Detail	2562	C57BL/6
polypeptide	Q921L8	UniProt \| EBI \| MGI Sequence Detail	608	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007820 polypeptide N-acetylgalactosaminyltransferase 11

(term hierarchy)
EC

2.4.1.41
InterPro Domains

IPR001173 Glycosyltransferase 2-like

IPR045885 N-acetylgalactosaminyltransferase

IPR029044 Nucleotide-diphospho-sugar transferases

IPR000772 Ricin B, lectin domain

IPR035992 Ricin B-like lectins
GlyGen

Q921L8 2 sites, 1 N-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 2

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MGI:2140948, MGI:2443736

Summaries

All 46

Developmental Gene Expression 6

Diseases 1

Gene Ontology 5

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:296164 Bubier JA, et al., Genetic variation regulates opioid-induced respiratory depression in mice. Sci Rep. 2020 Sep 11;10(1):14970

TSS for Galnt11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45458	Chr5:25427842-25427853 (+)	116 bp
Tssr45459	Chr5:25427860-25427949 (+)	173 bp
Tssr45460	Chr5:25451773-25451800 (+)	24,055 bp
Tssr45461	Chr5:25452342-25452354 (+)	24,616 bp
Tssr45462	Chr5:25452368-25452379 (+)	24,642 bp
Tssr45463	Chr5:25452383-25452407 (+)	24,663 bp
Tssr45464	Chr5:25453476-25453479 (+)	25,746 bp
Tssr45465	Chr5:25454981-25454999 (+)	27,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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