Phf20l1 MGI Mouse Gene Detail - MGI:2444412 - PHD finger protein 20-like 1

Symbol

Phf20l1
Name

PHD finger protein 20-like 1
Synonyms

CGI-72, E130113K22Rik

Feature Type

protein coding gene
IDs

MGI:2444412
NCBI Gene: 239510
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:66449409-66519825 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.30 cM
Mapping Data

2 experiments

SNPs within 2kb

1271 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444412	protein coding gene	Chr15:66449354-66519825 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021906	protein coding gene	Chr15:66090888-66164112 (+)
A/J	MGP_AJ_G0021865	protein coding gene	Chr15:63586269-63652665 (+)
AKR/J	MGP_AKRJ_G0021847	protein coding gene	Chr15:65346459-65415753 (+)
BALB/cJ	MGP_BALBcJ_G0021872	protein coding gene	Chr15:63771872-63837374 (+)
C3H/HeJ	MGP_C3HHeJ_G0021645	protein coding gene	Chr15:65460694-65529879 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022311	protein coding gene	Chr15:68660401-68729733 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019848	protein coding gene	Chr15:60371970-60440208 (+)
CAST/EiJ	MGP_CASTEiJ_G0021164	protein coding gene	Chr15:66120126-66189252 (+)
CBA/J	MGP_CBAJ_G0021611	protein coding gene	Chr15:70926810-71007241 (+)
DBA/2J	MGP_DBA2J_G0021736	protein coding gene	Chr15:63370903-63440348 (+)
FVB/NJ	MGP_FVBNJ_G0021718	protein coding gene	Chr15:62407903-62472845 (+)
LP/J	MGP_LPJ_G0021808	protein coding gene	Chr15:65983777-66053930 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021741	protein coding gene	Chr15:76024647-76117791 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022333	protein coding gene	Chr15:65723522-65791828 (+)
PWK/PhJ	MGP_PWKPhJ_G0020905	protein coding gene	Chr15:63463380-63532171 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020746	protein coding gene	Chr15:65582879-65654996 (+)
WSB/EiJ	MGP_WSBEiJ_G0021216	protein coding gene	Chr15:65695062-65766663 (+)

Human Ortholog

PHF20L1, PHD finger protein 20 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHF20L1, PHD finger protein 20 like 1
Synonyms

CGI-72, TDRD20B, URLC1
Links

HGNC:24280

NCBI Gene ID: 51105

neXtProt AC: NX_A8MW92

UniProt: A8MW92
Chr Location

8q24.22; chr8:132775358-132848807 (+) GRCh38

MGI Vertebrate Homology

Phf20l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHF20L1
Gene Tree

Phf20l1

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

3
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Phf20l1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

19
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phf20l1

ZFIN phf20l1

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All Sequences

146
RefSeq

79
UniProt

7
CCDS

CCDS49621.1

Ensembl

ENSMUSG00000072501 (Evidence)
NCBI Gene

239510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000072501	Ensembl Gene Model \| MGI Sequence Detail	70417	C57BL/6J	± kb
transcript	ENSMUST00000048188	Ensembl \| MGI Sequence Detail	6665	Not Applicable
polypeptide	ENSMUSP00000035682	Ensembl \| MGI Sequence Detail	1014	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031030 PHD finger protein 20-like protein 1

(term hierarchy)
InterPro Domains

IPR014002 Agenet domain, plant type

IPR040477 Lysine-specific demethylase 4-like, Tudor domain

IPR043449 PHD finger protein 20-like

IPR047405 PHD finger protein 20-like protein 1, Tudor domain

IPR002999 Tudor domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 8

Summaries

All 61

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Phf20l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131468	Chr15:66449371-66449382 (+)	-32 bp
Tssr131469	Chr15:66449385-66449486 (+)	27 bp
Tssr131470	Chr15:66451031-66451034 (+)	1,624 bp
Tssr131471	Chr15:66475929-66475940 (+)	26,526 bp
Tssr131472	Chr15:66487566-66487583 (+)	38,166 bp
Tssr131473	Chr15:66487612-66487648 (+)	38,221 bp
Tssr131474	Chr15:66514748-66514773 (+)	65,352 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24