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Usp43 Gene Detail
Summary
  • Symbol
    Usp43
  • Name
    ubiquitin specific peptidase 43
  • Synonyms
    C630032K07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444541
    NCBI Gene: 216835
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67745349-67812979 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1876 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444541
 protein coding gene Chr11:67745349-67812979 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018496
 protein coding gene Chr11:68177759-68240152 (-)
A/J MGP_AJ_G0018465
 protein coding gene Chr11:65627186-65690980 (-)
AKR/J MGP_AKRJ_G0018434
 protein coding gene Chr11:67587498-67649707 (-)
BALB/cJ MGP_BALBcJ_G0018436
 protein coding gene Chr11:65907974-65973702 (-)
C3H/HeJ MGP_C3HHeJ_G0018249
 protein coding gene Chr11:67606302-67670820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018888
 protein coding gene Chr11:70257333-70326132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016532
 protein coding gene Chr11:62579507-62641581 (-)
CAST/EiJ MGP_CASTEiJ_G0017805
 protein coding gene Chr11:67823144-67885529 (-)
CBA/J MGP_CBAJ_G0018223
 protein coding gene Chr11:73359241-73440605 (-)
DBA/2J MGP_DBA2J_G0018332
 protein coding gene Chr11:65232399-65295561 (-)
FVB/NJ MGP_FVBNJ_G0018322
 protein coding gene Chr11:64841464-64904236 (-)
LP/J MGP_LPJ_G0018403
 protein coding gene Chr11:68751726-68815203 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018345
 protein coding gene Chr11:74110109-74176674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018929
 protein coding gene Chr11:67842386-67901556 (-)
PWK/PhJ MGP_PWKPhJ_G0017580
 protein coding gene Chr11:65845791-65908461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017368
 protein coding gene Chr11:67661136-67730501 (-)
WSB/EiJ MGP_WSBEiJ_G0017858
 protein coding gene Chr11:67443959-67509794 (-)



Homology
more
  • Human Ortholog
    USP43, ubiquitin specific peptidase 43
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP43, ubiquitin specific peptidase 43
  • Links
    NCBI Gene ID: 124739
    neXtProt AC: NX_Q70EL4
    UniProt: Q70EL4

  • Chr Location
    17p13.1; chr17:9644698-9729687 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 216835 NCBI Gene Model | MGI Sequence Detail 67631 C57BL/6J ±  kb
transcript NM_173754 RefSeq | MGI Sequence Detail 4462 C57BL/6  
polypeptide Q8BUM9 UniProt | EBI | MGI Sequence Detail 1132 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017182 ubiquitin carboxyl-terminal hydrolase 43
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR050185 Ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
  • GlyGen
    Q8BUM9 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory