Tafa4 MGI Mouse Gene Detail - MGI:2444563 - TAFA chemokine like family member 4

Symbol

Tafa4
Name

TAFA chemokine like family member 4
Synonyms

C130034I18Rik, Fam19a4, Tafa4

Feature Type

protein coding gene
IDs

MGI:2444563
NCBI Gene: 320701
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:96808164-97037374 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 44.80 cM
Mapping Data

1 experiment

SNPs within 2kb

5608 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444563	protein coding gene	Chr6:96808164-97037452 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031071	protein coding gene	Chr6:98648825-98886756 (-)
A/J	MGP_AJ_G0031040	protein coding gene	Chr6:94917395-95145132 (-)
AKR/J	MGP_AKRJ_G0030971	protein coding gene	Chr6:97542507-97772831 (-)
BALB/cJ	MGP_BALBcJ_G0031051	protein coding gene	Chr6:94867909-95094704 (-)
C3H/HeJ	MGP_C3HHeJ_G0030657	protein coding gene	Chr6:86673521-86888832 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031510	protein coding gene	Chr6:101145668-101387037 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028675	protein coding gene	Chr6:92787882-92968746 (-)
CAST/EiJ	MGP_CASTEiJ_G0030158	protein coding gene	Chr6:97719808-97936742 (-)
CBA/J	MGP_CBAJ_G0030737	protein coding gene	Chr6:104971453-105241662 (-)
DBA/2J	MGP_DBA2J_G0030890	protein coding gene	Chr6:94051635-94288626 (-)
FVB/NJ	MGP_FVBNJ_G0030844	protein coding gene	Chr6:93238351-93466295 (-)
LP/J	MGP_LPJ_G0030970	protein coding gene	Chr6:98668667-98901010 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030878	protein coding gene	Chr6:108938455-109177454 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031537	protein coding gene	Chr6:97410562-97630881 (-)
PWK/PhJ	MGP_PWKPhJ_G0029874	protein coding gene	Chr6:93056074-93267665 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029702	protein coding gene	Chr6:96308962-96540069 (-)
WSB/EiJ	MGP_WSBEiJ_G0030242	protein coding gene	Chr6:97860156-98090595 (-)

Human Ortholog

TAFA4, TAFA chemokine like family member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAFA4, TAFA chemokine like family member 4
Synonyms

FAM19A4, TAFA-4
Links

HGNC:21591

NCBI Gene ID: 151647

neXtProt AC: NX_Q96LR4

UniProt: Q96LR4
Chr Location

3p14.1

MGI Vertebrate Homology

Tafa4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAFA4
Gene Tree

Tafa4

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

3
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Tafa4
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased mechanical and chemical nociception following inflammation or injury due to alterations in lamina IIi neuron excitability.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

15
cDNA Data

6
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tafa4

ZFIN tafa4b

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All Sequences

41
RefSeq

10
UniProt

1
CCDS

CCDS51858.1

Ensembl

ENSMUSG00000046500 (Evidence)
NCBI Gene

320701

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046500	Ensembl Gene Model \| MGI Sequence Detail	229211	C57BL/6J	± kb
transcript	ENSMUST00000089295	Ensembl \| MGI Sequence Detail	2190	Not Applicable
polypeptide	ENSMUSP00000086710	Ensembl \| MGI Sequence Detail	135	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032648 chemokine-like protein TAFA-4

(term hierarchy)
InterPro Domains

IPR020350 Chemokine-like protein TAFA

IPR051743 TAFA chemokine-like

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All nucleic 6

cDNA 6

Microarray probesets 2

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MGI:6276246

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 20
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;

TSS for Tafa4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62194	Chr6:97037368-97037381 (-)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24