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Ipo8 Gene Detail
Summary
  • Symbol
    Ipo8
  • Name
    importin 8
  • Synonyms
    6230418K12Rik, C130009K11Rik, Om1, OM-1, Ranbp8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444611
    NCBI Gene: 320727
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:148672181-148732965 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 78.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444611
 protein coding gene Chr6:148672181-148732977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031504
 protein coding gene Chr6:153871777-153934060 (-)
A/J MGP_AJ_G0031479
 protein coding gene Chr6:147760115-147821500 (-)
AKR/J MGP_AKRJ_G0031407
 protein coding gene Chr6:152164265-152225482 (-)
BALB/cJ MGP_BALBcJ_G0031487
 protein coding gene Chr6:147524340-147588010 (-)
C3H/HeJ MGP_C3HHeJ_G0031208
 protein coding gene Chr6:152211471-152279465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031948
 protein coding gene Chr6:157957030-158025308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029072
 protein coding gene Chr6:146479716-146541845 (-)
CAST/EiJ MGP_CASTEiJ_G0030577
 protein coding gene Chr6:151891591-151957515 (-)
CBA/J MGP_CBAJ_G0031168
 protein coding gene Chr6:164035559-164100787 (-)
DBA/2J MGP_DBA2J_G0031324
 protein coding gene Chr6:146553268-146617160 (-)
FVB/NJ MGP_FVBNJ_G0031276
 protein coding gene Chr6:145246181-145311827 (-)
LP/J MGP_LPJ_G0031410
 protein coding gene Chr6:154003153-154067415 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031316
 protein coding gene Chr6:167656484-167731223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031981
 protein coding gene Chr6:152021395-152086000 (-)
PWK/PhJ MGP_PWKPhJ_G0030303
 protein coding gene Chr6:145066437-145134596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030127
 protein coding gene Chr6:150123026-150187814 (-)
WSB/EiJ MGP_WSBEiJ_G0030670
 protein coding gene Chr6:152636217-152701809 (-)



Homology
more
  • Human Ortholog
    IPO8, importin 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IPO8, importin 8
  • Synonyms
    RANBP8, VISS
  • Links
    NCBI Gene ID: 10526
    neXtProt AC: NX_O15397
    UniProt: O15397

  • Chr Location
    12p11.21; chr12:30628988-30695869 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    86
  • cDNA Data
    185
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040029 Ensembl Gene Model | MGI Sequence Detail 60785 C57BL/6J ±  kb
    transcript ENSMUST00000048418 Ensembl | MGI Sequence Detail 5360 Not Applicable  
    polypeptide ENSMUSP00000046759 Ensembl | MGI Sequence Detail 1010 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 189
      cDNA 185
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1354177, MGI:2665219
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:1385 Salles FJ, et al., Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev. 1992 Jul;6(7):1202-12
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory