Mdga2 MGI Mouse Gene Detail - MGI:2444706 - MAM domain containing glycosylphosphatidylinositol anchor 2

Symbol

Mdga2
Name

MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms

6720489L24Rik, 9330209L04Rik, Adp, Mamdc1, Mdga2

Feature Type

protein coding gene
IDs

MGI:2444706
NCBI Gene: 320772
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:66512834-67269323 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 27.63 cM
Mapping Data

2 experiments

SNPs within 2kb

23406 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444706	protein coding gene	Chr12:66512832-67269323 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019784	protein coding gene	Chr12:65998178-66824960 (-)
A/J	MGP_AJ_G0019742	protein coding gene	Chr12:63580635-64353506 (-)
AKR/J	MGP_AKRJ_G0019718	protein coding gene	Chr12:65575227-66345385 (-)
BALB/cJ	MGP_BALBcJ_G0019722	protein coding gene	Chr12:64047497-64818922 (-)
C3H/HeJ	MGP_C3HHeJ_G0019528	protein coding gene	Chr12:65933531-66738302 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020174	protein coding gene	Chr12:68112142-68940246 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017794	protein coding gene	Chr12:61317365-62070175 (-)
CAST/EiJ	MGP_CASTEiJ_G0019079	protein coding gene	Chr12:60656020-61482556 (-)
CBA/J	MGP_CBAJ_G0019497	protein coding gene	Chr12:70575185-71474216 (-)
DBA/2J	MGP_DBA2J_G0019613	protein coding gene	Chr12:63496833-64288675 (-)
FVB/NJ	MGP_FVBNJ_G0019601	protein coding gene	Chr12:62473893-63236774 (-)
LP/J	MGP_LPJ_G0019685	protein coding gene	Chr12:66010947-66815525 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019639	protein coding gene	Chr12:73576070-74601699 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020209	protein coding gene	Chr12:64978115-65762292 (-)
PWK/PhJ	MGP_PWKPhJ_G0018845	protein coding gene	Chr12:57766755-58544789 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018640	protein coding gene	Chr12:59344487-60183574 (-)
WSB/EiJ	MGP_WSBEiJ_G0019130	protein coding gene	Chr12:65512825-66322111 (-)

Human Ortholog

MDGA2, MAM domain containing glycosylphosphatidylinositol anchor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MDGA2, MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms

c14_5286, MAMDC1
Links

HGNC:19835

NCBI Gene ID: 161357

neXtProt AC: NX_Q7Z553

UniProt: Q7Z553
Chr Location

14q21.3; chr14:46839623-47675605 (-) GRCh38

MGI Vertebrate Homology

Mdga2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MDGA2
Gene Tree

Mdga2

less

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
27 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

2
Targeted

3
Transgenic

2
Genomic Mutations

1 involving Mdga2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice that paternally inherit an allele disrupted by transgene insertion exhibit varying degrees of abnormalities in the skull, paw, and tail.

less

All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

17
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mdga2

ZFIN mdga2a

less

All Sequences

77
RefSeq

12
UniProt

10
CCDS

CCDS25945.1, CCDS56842.2

Ensembl

ENSMUSG00000034912 (Evidence)
NCBI Gene

320772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034912	Ensembl Gene Model \| MGI Sequence Detail	756490	C57BL/6J	± kb
transcript	ENSMUST00000037181	Ensembl \| MGI Sequence Detail	9833	Not Applicable
polypeptide	ENSMUSP00000046761	Ensembl \| MGI Sequence Detail	1025	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000010262 MAM domain-containing glycosylphosphatidylinositol anchor protein 2

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR050876 IgLON domain-containing protein

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR000998 MAM domain

IPR051560 MAM domain-containing protein
GlyGen

P60755 9 sites, 8 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

less

All nucleic 20

Genomic 1

cDNA 19

Microarray probesets 5

less

MGD-MRK-1131, MGI:2443365, MGI:5906302, MGI:87932

Summaries

All 44

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 15
Earliest

J:82720 DeLoia JA, et al., A transgene insertional mutation at an imprinted locus in the mouse genome. Dev Suppl. 1990;:73-9
Latest

J:320476 Chen P, et al., DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. J Neurosci. 2022 Jan 26;42(4):532-551

TSS for Mdga2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116481	Chr12:67269363-67269374 (-)	-46 bp
Tssr116480	Chr12:67269324-67269352 (-)	-15 bp
Tssr116479	Chr12:67256294-67256298 (-)	13,027 bp
Tssr116478	Chr12:67240714-67240757 (-)	28,587 bp
Tssr116476	Chr12:67157360-67157363 (-)	111,961 bp
Tssr116475	Chr12:67128890-67128897 (-)	140,429 bp
Tssr116474	Chr12:67106671-67106697 (-)	162,639 bp
Tssr116473	Chr12:67106175-67106225 (-)	163,123 bp
Tssr116472	Chr12:66607726-66607755 (-)	661,582 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24