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Mdga2 Gene Detail
Summary
  • Symbol
    Mdga2
  • Name
    MAM domain containing glycosylphosphatidylinositol anchor 2
  • Synonyms
    6720489L24Rik, 9330209L04Rik, Adp, Mamdc1, Mdga2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444706
    NCBI Gene: 320772
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:66512834-67269323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 27.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23406 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444706
 protein coding gene Chr12:66512832-67269323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019784
 protein coding gene Chr12:65998178-66824960 (-)
A/J MGP_AJ_G0019742
 protein coding gene Chr12:63580635-64353506 (-)
AKR/J MGP_AKRJ_G0019718
 protein coding gene Chr12:65575227-66345385 (-)
BALB/cJ MGP_BALBcJ_G0019722
 protein coding gene Chr12:64047497-64818922 (-)
C3H/HeJ MGP_C3HHeJ_G0019528
 protein coding gene Chr12:65933531-66738302 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020174
 protein coding gene Chr12:68112142-68940246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017794
 protein coding gene Chr12:61317365-62070175 (-)
CAST/EiJ MGP_CASTEiJ_G0019079
 protein coding gene Chr12:60656020-61482556 (-)
CBA/J MGP_CBAJ_G0019497
 protein coding gene Chr12:70575185-71474216 (-)
DBA/2J MGP_DBA2J_G0019613
 protein coding gene Chr12:63496833-64288675 (-)
FVB/NJ MGP_FVBNJ_G0019601
 protein coding gene Chr12:62473893-63236774 (-)
LP/J MGP_LPJ_G0019685
 protein coding gene Chr12:66010947-66815525 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019639
 protein coding gene Chr12:73576070-74601699 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020209
 protein coding gene Chr12:64978115-65762292 (-)
PWK/PhJ MGP_PWKPhJ_G0018845
 protein coding gene Chr12:57766755-58544789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018640
 protein coding gene Chr12:59344487-60183574 (-)
WSB/EiJ MGP_WSBEiJ_G0019130
 protein coding gene Chr12:65512825-66322111 (-)



Homology
more
  • Human Ortholog
    MDGA2, MAM domain containing glycosylphosphatidylinositol anchor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDGA2, MAM domain containing glycosylphosphatidylinositol anchor 2
  • Synonyms
    c14_5286, MAMDC1
  • Links
    NCBI Gene ID: 161357
    neXtProt AC: NX_Q7Z553
    UniProt: Q7Z553

  • Chr Location
    14q21.3; chr14:46839623-47675605 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    27 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that paternally inherit an allele disrupted by transgene insertion exhibit varying degrees of abnormalities in the skull, paw, and tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034912 Ensembl Gene Model | MGI Sequence Detail 756490 C57BL/6J ±  kb
    transcript ENSMUST00000037181 Ensembl | MGI Sequence Detail 9833 Not Applicable  
    polypeptide ENSMUSP00000046761 Ensembl | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1131, MGI:2443365, MGI:5906302, MGI:87932
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:82720 DeLoia JA, et al., A transgene insertional mutation at an imprinted locus in the mouse genome. Dev Suppl. 1990;:73-9
    • Latest
      J:320476 Chen P, et al., DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. J Neurosci. 2022 Jan 26;42(4):532-551
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory