Shisa2 MGI Mouse Gene Detail - MGI:2444716

Symbol

Shisa2
Name

shisa family member 2
Synonyms

9430059P22Rik, MAd2, mShisa, shisa, Tmem46

Feature Type

protein coding gene
IDs

MGI:2444716
NCBI Gene: 219134
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:59862757-59869109 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 31.49 cM
Mapping Data

1 experiment

SNPs within 2kb

152 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444716	protein coding gene	Chr14:59862730-59869109 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021427	protein coding gene	Chr14:53941209-53947586 (+)
A/J	MGP_AJ_G0021386	protein coding gene	Chr14:52801225-52807600 (+)
AKR/J	MGP_AKRJ_G0021361	protein coding gene	Chr14:54674760-54681130 (+)
BALB/cJ	MGP_BALBcJ_G0021391	protein coding gene	Chr14:52763063-52769439 (+)
C3H/HeJ	MGP_C3HHeJ_G0021169	protein coding gene	Chr14:54334895-54341265 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021830	protein coding gene	Chr14:56618620-56624997 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019370	protein coding gene	Chr14:50849631-50856112 (+)
CAST/EiJ	MGP_CASTEiJ_G0020685	protein coding gene	Chr14:50744816-50751174 (+)
CBA/J	MGP_CBAJ_G0021136	protein coding gene	Chr14:58222705-58229072 (+)
DBA/2J	MGP_DBA2J_G0021259	protein coding gene	Chr14:52472947-52479317 (+)
FVB/NJ	MGP_FVBNJ_G0021237	protein coding gene	Chr14:51885520-51891897 (+)
LP/J	MGP_LPJ_G0021333	protein coding gene	Chr14:54967748-54974113 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021266	protein coding gene	Chr14:57625873-57632250 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021853	protein coding gene	Chr14:53815508-53821885 (+)
PWK/PhJ	MGP_PWKPhJ_G0020429	protein coding gene	Chr14:49115517-49121967 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020262	protein coding gene	Chr14:49816826-49823233 (+)
WSB/EiJ	MGP_WSBEiJ_G0020738	protein coding gene	Chr14:54134545-54140914 (+)

Human Ortholog

SHISA2, shisa family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHISA2, shisa family member 2
Synonyms

bA398O19.2, C13orf13, hShisa, PRO28631, TMEM46, WGAR9166
Links

HGNC:20366

NCBI Gene ID: 387914

neXtProt AC: NX_Q6UWI4

UniProt: Q6UWI4
Chr Location

13q12.13

MGI Vertebrate Homology

Shisa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SHISA2
Gene Tree

Shisa2

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Shisa2
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null alle exhibit dwarfism, delayed growth and postnatal lethality with abnormal hypothalamus morphology.

less

All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

77
cDNA Data

49
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SHISA2

Xenbase shisa2

ZFIN shisa2a

less

All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS27173.1

Ensembl

ENSMUSG00000044461 (Evidence)
NCBI Gene

219134

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044461	Ensembl Gene Model \| MGI Sequence Detail	6353	C57BL/6J	± kb
transcript	ENSMUST00000053949	Ensembl \| MGI Sequence Detail	3119	Not Applicable
polypeptide	ENSMUSP00000059391	Ensembl \| MGI Sequence Detail	295	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000014842 protein shisa-2

(term hierarchy)
InterPro Domains

IPR026910 Shisa family
GlyGen

Q8QZV2 1 site, 1 O-linked glycan (1 site)

less

All nucleic 54

cDNA 49

Primer pair 1

Other 4

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 17

Gene Ontology 3

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:349775 Matern MS, et al., Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Rep. 2023 Jun 27;42(6):112545

TSS for Shisa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125914	Chr14:59862727-59862740 (+)	-23 bp
Tssr125915	Chr14:59862751-59862767 (+)	2 bp
Tssr125916	Chr14:59863009-59863035 (+)	265 bp
Tssr125917	Chr14:59863758-59863769 (+)	1,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24