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Camkk2 Gene Detail
Summary
  • Symbol
    Camkk2
  • Name
    calcium/calmodulin-dependent protein kinase kinase 2, beta
  • Synonyms
    6330570N16Rik, mKIAA0787
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444812
    NCBI Gene: 207565
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122869233-122917472 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444812
 protein coding gene Chr5:122856064-122918295 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030057
 protein coding gene Chr5:126381315-126427559 (-)
A/J MGP_AJ_G0030022
 protein coding gene Chr5:121143593-121195600 (-)
AKR/J MGP_AKRJ_G0029958
 protein coding gene Chr5:125051085-125100351 (-)
BALB/cJ MGP_BALBcJ_G0030033
 protein coding gene Chr5:122491815-122538560 (-)
C3H/HeJ MGP_C3HHeJ_G0029750
 protein coding gene Chr5:125678372-125724621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030486
 protein coding gene Chr5:131259797-131313018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027712
 protein coding gene Chr5:115750199-115798679 (-)
CAST/EiJ MGP_CASTEiJ_G0029159
 protein coding gene Chr5:124759117-124810797 (-)
CBA/J MGP_CBAJ_G0029720
 protein coding gene Chr5:136388878-136446964 (-)
DBA/2J MGP_DBA2J_G0029870
 protein coding gene Chr5:121201723-121248570 (-)
FVB/NJ MGP_FVBNJ_G0029826
 protein coding gene Chr5:120204319-120251200 (-)
LP/J MGP_LPJ_G0029959
 protein coding gene Chr5:126920840-126977414 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029857
 protein coding gene Chr5:140105629-140151841 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030527
 protein coding gene Chr5:124647408-124695425 (-)
PWK/PhJ MGP_PWKPhJ_G0028873
 protein coding gene Chr5:119983558-120035890 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028710
 protein coding gene Chr5:122358799-122408159 (-)
WSB/EiJ MGP_WSBEiJ_G0029234
 protein coding gene Chr5:125311224-125365228 (-)



Homology
more
  • Human Ortholog
    CAMKK2, calcium/calmodulin dependent protein kinase kinase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAMKK2, calcium/calmodulin dependent protein kinase kinase 2
  • Synonyms
    CAMKK, CAMKKB
  • Links
    NCBI Gene ID: 10645
    neXtProt AC: NX_Q96RR4
    UniProt: Q96RR4

  • Chr Location
    12q24.31; chr12:121237675-121298308 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in impaird long term potentiation and defects in some types of long term memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    19
  • cDNA Data
    51
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029471 Ensembl Gene Model | MGI Sequence Detail 48240 C57BL/6J ±  kb
    transcript ENSMUST00000111668 Ensembl | MGI Sequence Detail 4861 Not Applicable  
    polypeptide ENSMUSP00000107297 Ensembl | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141148
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 45
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352177 Virga DM, et al., Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Nat Commun. 2024 Mar 8;15(1):2142
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory