Dglucy MGI Mouse Gene Detail - MGI:2444813

Symbol

Dglucy
Name

D-glutamate cyclase
Synonyms

9030617O03Rik

Feature Type

protein coding gene
IDs

MGI:2444813
NCBI Gene: 217830
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:100745316-100838869 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.10 cM
Mapping Data

1 experiment

SNPs within 2kb

2395 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444813	protein coding gene	Chr12:100745316-100863240 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020020	protein coding gene	Chr12:102263801-102384095 (+)
A/J	MGP_AJ_G0019975	protein coding gene	Chr12:98423433-98530067 (+)
AKR/J	MGP_AKRJ_G0019951	protein coding gene	Chr12:101097703-101223048 (+)
BALB/cJ	MGP_BALBcJ_G0019961	protein coding gene	Chr12:98770285-98882854 (+)
C3H/HeJ	MGP_C3HHeJ_G0019763	protein coding gene	Chr12:101630294-101752305 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020410	protein coding gene	Chr12:105439809-105557385 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018024	protein coding gene	Chr12:95394332-95510521 (+)
CAST/EiJ	MGP_CASTEiJ_G0019309	protein coding gene	Chr12:96744500-96863616 (+)
CBA/J	MGP_CBAJ_G0019735	protein coding gene	Chr12:109319725-109459055 (+)
DBA/2J	MGP_DBA2J_G0019846	protein coding gene	Chr12:97863760-97982420 (+)
FVB/NJ	MGP_FVBNJ_G0019835	protein coding gene	Chr12:96585758-96701914 (+)
LP/J	MGP_LPJ_G0019922	protein coding gene	Chr12:102119081-102240140 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019877	protein coding gene	Chr12:112913122-113041669 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020439	protein coding gene	Chr12:100667727-100792390 (+)
PWK/PhJ	MGP_PWKPhJ_G0019073	protein coding gene	Chr12:92506979-92622558 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018869	protein coding gene	Chr12:94860616-94978222 (+)
WSB/EiJ	MGP_WSBEiJ_G0019363	protein coding gene	Chr12:101529048-101656649 (+)

Human Ortholog

DGLUCY, D-glutamate cyclase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DGLUCY, D-glutamate cyclase
Synonyms

C14orf159
Links

HGNC:20498

NCBI Gene ID: 80017

neXtProt AC: NX_Q7Z3D6

UniProt: Q7Z3D6
Chr Location

14q32.11; chr14:91060333-91225632 (+) GRCh38

MGI Vertebrate Homology

Dglucy stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DGLUCY
Protein SuperFamily

UCP037204
Gene Tree

Dglucy

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Dglucy
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a knock-out allele exhibit elevated D-glutamate levels in the heart.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

17
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dglucy

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All Sequences

66
RefSeq

16
UniProt

5
CCDS

CCDS26108.1, CCDS88389.1

Ensembl

ENSMUSG00000021185 (Evidence)
NCBI Gene

217830

			Length	Strain/Species	Flank
genomic	217830	NCBI Gene Model \| MGI Sequence Detail	93554	C57BL/6J	± kb
transcript	NM_001361017	RefSeq \| MGI Sequence Detail	3461	C57BL/6
polypeptide	Q8BH86	UniProt \| EBI \| MGI Sequence Detail	617	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000059893 D-glutamate cyclase, mitochondrial

(term hierarchy)
EC

4.2.1.48
InterPro Domains

IPR009906 D-glutamate cyclase

IPR025504 D-glutamate cyclase-like, C-terminal

IPR017135 D-glutamate cyclase, mitochondrial

IPR038021 Putative hydro-lyase

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 3

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MGI:5904980

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:241368 Ariyoshi M, et al., D-Glutamate is metabolized in the heart mitochondria. Sci Rep. 2017 Mar 07;7:43911

TSS for Dglucy:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114712	Chr12:100745314-100745324 (+)	3 bp
Tssr114713	Chr12:100745333-100745344 (+)	23 bp
Tssr114714	Chr12:100745347-100745360 (+)	38 bp
Tssr114715	Chr12:100745364-100745396 (+)	64 bp
Tssr114716	Chr12:100745399-100745415 (+)	91 bp
Tssr114717	Chr12:100822333-100822341 (+)	77,021 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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