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Lrit2 Gene Detail
Summary
  • Symbol
    Lrit2
  • Name
    leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
  • Synonyms
    A930010E21Rik, Lrrc22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444885
    NCBI Gene: 239038
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:36789886-36795700 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 21.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444885
 protein coding gene Chr14:36784923-36795700 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021186
 protein coding gene Chr14:30569018-30574639 (+)
A/J MGP_AJ_G0021134
 protein coding gene Chr14:29303733-29309888 (+)
AKR/J MGP_AKRJ_G0021111
 protein coding gene Chr14:30641702-30647292 (+)
BALB/cJ MGP_BALBcJ_G0021138
 protein coding gene Chr14:29535376-29541979 (+)
C3H/HeJ MGP_C3HHeJ_G0020921
 protein coding gene Chr14:30523879-30529511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021570
 protein coding gene Chr14:31665595-31671179 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019132
 protein coding gene Chr14:29288179-29294050 (+)
CAST/EiJ MGP_CASTEiJ_G0020446
 protein coding gene Chr14:30410573-30416919 (+)
CBA/J MGP_CBAJ_G0020887
 protein coding gene Chr14:32846343-32853489 (+)
DBA/2J MGP_DBA2J_G0021010
 protein coding gene Chr14:29344838-29350452 (+)
FVB/NJ MGP_FVBNJ_G0020994
 protein coding gene Chr14:29321847-29327528 (+)
LP/J MGP_LPJ_G0021079
 protein coding gene Chr14:30862651-30869905 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021020
 protein coding gene Chr14:32049347-32055956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021603
 protein coding gene Chr14:30503628-30509246 (+)
PWK/PhJ MGP_PWKPhJ_G0020194
 protein coding gene Chr14:28887714-28894522 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020018
 protein coding gene Chr14:30050979-30057854 (+)
WSB/EiJ MGP_WSBEiJ_G0020501
 protein coding gene Chr14:30529934-30535768 (+)



Homology
more
  • Human Ortholog
    LRIT2, leucine rich repeat, Ig-like and transmembrane domains 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRIT2, leucine rich repeat, Ig-like and transmembrane domains 2
  • Synonyms
    LRRC22
  • Links
    NCBI Gene ID: 340745
    neXtProt AC: NX_A6NDA9
    UniProt: A6NDA9

  • Chr Location
    10q23.1; chr10:84220485-84225589 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    17
  • cDNA Data
    15
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043418 Ensembl Gene Model | MGI Sequence Detail 5815 C57BL/6J ±  kb
transcript ENSMUST00000057176 Ensembl | MGI Sequence Detail 2790 Not Applicable  
polypeptide ENSMUSP00000056642 Ensembl | MGI Sequence Detail 549 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000032750 leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR036116 Fibronectin type III superfamily
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    Q6PFC5 3 sites
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:271244 Ueno A, et al., Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018 Mar 27;22(13):3548-3561
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory