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Spin4 Gene Detail
Summary
  • Symbol
    Spin4
  • Name
    spindlin family, member 4
  • Synonyms
    9630042H07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444925
    NCBI Gene: 270624
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:94066116-94070288 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444925
 protein coding gene ChrX:94066113-94070288 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035915
 protein coding gene ChrX:91361071-91365121 (-)
A/J MGP_AJ_G0035901
 protein coding gene ChrX:91569525-91576333 (-)
AKR/J MGP_AKRJ_G0035817
 protein coding gene ChrX:93977861-93982035 (-)
BALB/cJ MGP_BALBcJ_G0035885
 protein coding gene ChrX:90314186-90318723 (-)
C3H/HeJ MGP_C3HHeJ_G0035593
 protein coding gene ChrX:91851341-91856152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036414
 protein coding gene ChrX:94260930-94266203 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033241
 protein coding gene ChrX:89679066-89683264 (-)
CAST/EiJ MGP_CASTEiJ_G0034879
 protein coding gene ChrX:76393836-76398022 (-)
CBA/J MGP_CBAJ_G0035568
 protein coding gene ChrX:97014108-97017579 (-)
DBA/2J MGP_DBA2J_G0035723
 protein coding gene ChrX:90763976-90768109 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0035813
 protein coding gene ChrX:92356588-92360672 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036441
 protein coding gene ChrX:91091454-91095628 (-)
PWK/PhJ MGP_PWKPhJ_G0034578
 protein coding gene ChrX:74084701-74088870 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034407
 protein coding gene ChrX:77191966-77196697 (-)
WSB/EiJ MGP_WSBEiJ_G0035019
 protein coding gene ChrX:89960492-89964514 (-)



Homology
more
  • Human Ortholog
    SPIN4, spindlin family member 4
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPIN4, spindlin family member 4
  • Synonyms
    LJBS, TDRD28
  • Links
    NCBI Gene ID: 139886
    neXtProt AC: NX_Q56A73
    UniProt: Q56A73

  • Chr Location
    Xq11.1; chrX:63347228-63351332 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with truncating mutations in this gene show increased overall body size, overgrowth of multiple organs, and increased longitudinal bone growth with increased cell proliferation in the proliferative zone and an increased number of progenitor chondrocytes in the resting zone of the tibial growth plate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071722 Ensembl Gene Model | MGI Sequence Detail 4173 C57BL/6J ±  kb
    transcript ENSMUST00000096367 Ensembl | MGI Sequence Detail 4173 Not Applicable  
    polypeptide ENSMUSP00000094095 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 19
      Gene Ontology 5
      Phenotypes 1
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:347154 Lui JC, et al., Loss-of-function variant in SPIN4 causes an X-linked overgrowth syndrome. JCI Insight. 2023 May 8;8(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory