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Pla2g3 Gene Detail
Summary
  • Symbol
    Pla2g3
  • Name
    phospholipase A2, group III
  • Synonyms
    9130003P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444945
    NCBI Gene: 237625
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3438284-3449350 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444945
 protein coding gene Chr11:3438158-3449350 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017958
 protein coding gene Chr11:360776-371858 (+)
A/J MGP_AJ_G0017931
 protein coding gene Chr11:405900-416983 (+)
AKR/J MGP_AKRJ_G0017895
 protein coding gene Chr11:423812-434888 (+)
BALB/cJ MGP_BALBcJ_G0017899
 protein coding gene Chr11:377680-388736 (+)
C3H/HeJ MGP_C3HHeJ_G0017712
 protein coding gene Chr11:358712-369771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018352
 protein coding gene Chr11:431797-442859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016011
 protein coding gene Chr11:315204-326146 (+)
CAST/EiJ MGP_CASTEiJ_G0017274
 protein coding gene Chr11:312814-324156 (+)
CBA/J MGP_CBAJ_G0017687
 protein coding gene Chr11:596574-610662 (+)
DBA/2J MGP_DBA2J_G0017798
 protein coding gene Chr11:324527-335588 (+)
FVB/NJ MGP_FVBNJ_G0017789
 protein coding gene Chr11:355075-366146 (+)
LP/J MGP_LPJ_G0017868
 protein coding gene Chr11:458296-469168 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017815
 protein coding gene Chr11:343635-354741 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018391
 protein coding gene Chr11:434342-447230 (+)
PWK/PhJ MGP_PWKPhJ_G0017054
 protein coding gene Chr11:298861-310079 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016850
 protein coding gene Chr11:388529-399591 (+)
WSB/EiJ MGP_WSBEiJ_G0017328
 protein coding gene Chr11:311674-322746 (+)



Homology
more
  • Human Ortholog
    PLA2G3, phospholipase A2 group III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G3, phospholipase A2 group III
  • Synonyms
    GIII-SPLA2, sPLA2-III, SPLA2III
  • Links
    NCBI Gene ID: 50487
    neXtProt AC: NX_Q9NZ20
    UniProt: Q9NZ20

  • Chr Location
    22q12.2; chr22:31134807-31140508 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 2 genetic backgrounds
    5 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice have reduced male fertility with smaller litter size and decreased susceptibility to IgE antigen-induced passive systemic and cutaneous anaphylaxis due to impaired mast cell maturation, degranulation and histamine release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034579 Ensembl Gene Model | MGI Sequence Detail 11067 C57BL/6J ±  kb
    transcript ENSMUST00000064265 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000068699 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory