Ccdc186 MGI Mouse Gene Detail - MGI:2445022 - coiled-coil domain containing 186

Symbol

Ccdc186
Name

coiled-coil domain containing 186
Synonyms

1810028B20Rik, A630007B06Rik, Otg1

Feature Type

protein coding gene
IDs

MGI:2445022
NCBI Gene: 213993
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:56775913-56810622 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.99 cM
Mapping Data

2 experiments

SNPs within 2kb

1027 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445022	protein coding gene	Chr19:56775913-56810631 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025268	protein coding gene	Chr19:57165449-57202152 (-)
A/J	MGP_AJ_G0025244	protein coding gene	Chr19:54334905-54372956 (-)
AKR/J	MGP_AKRJ_G0025213	protein coding gene	Chr19:56055847-56091923 (-)
BALB/cJ	MGP_BALBcJ_G0025239	protein coding gene	Chr19:54415535-54450055 (-)
C3H/HeJ	MGP_C3HHeJ_G0024999	protein coding gene	Chr19:56290385-56326960 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025682	protein coding gene	Chr19:58541133-58578821 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023094	protein coding gene	Chr19:53257649-53292583 (-)
CAST/EiJ	MGP_CASTEiJ_G0024464	protein coding gene	Chr19:56317521-56351654 (-)
CBA/J	MGP_CBAJ_G0024979	protein coding gene	Chr19:61448166-61488190 (-)
DBA/2J	MGP_DBA2J_G0025111	protein coding gene	Chr19:54122417-54156670 (-)
FVB/NJ	MGP_FVBNJ_G0025072	protein coding gene	Chr19:53826886-53862214 (-)
LP/J	MGP_LPJ_G0025197	protein coding gene	Chr19:57019709-57056593 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025105	protein coding gene	Chr19:60710424-60747213 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025740	protein coding gene	Chr19:56261355-56296891 (-)
PWK/PhJ	MGP_PWKPhJ_G0024212	protein coding gene	Chr19:54089870-54124302 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024015	protein coding gene	Chr19:54939069-54975958 (-)
WSB/EiJ	MGP_WSBEiJ_G0024534	protein coding gene	Chr19:56399791-56436045 (-)

Human Ortholog

CCDC186, coiled-coil domain containing 186

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC186, coiled-coil domain containing 186
Synonyms

C10orf118, CCCP-1, CCCP1, golgin104
Links

HGNC:24349

NCBI Gene ID: 55088

neXtProt AC: NX_Q7Z3E2

UniProt: Q7Z3E2
Chr Location

10q25.3; chr10:114120862-114174232 (-) GRCh38

MGI Vertebrate Homology

Ccdc186 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC186
Gene Tree

Ccdc186

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Transposon induced

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

12
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc186

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All Sequences

54
RefSeq

4
UniProt

2
CCDS

CCDS29921.1

Ensembl

ENSMUSG00000035173 (Evidence)
NCBI Gene

213993

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035173	Ensembl Gene Model \| MGI Sequence Detail	34710	C57BL/6J	± kb
transcript	ENSMUST00000118592	Ensembl \| MGI Sequence Detail	6445	Not Applicable
polypeptide	ENSMUSP00000113457	Ensembl \| MGI Sequence Detail	917	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059894 coiled-coil domain-containing protein 186

(term hierarchy)
InterPro Domains

IPR038830 Coiled-coil domain-containing protein 186
GlyGen

Q8C9S4 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 20

Genomic 2

cDNA 18

Microarray probesets 6

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MGI:1916382, MGI:2147482

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccdc186:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159887	Chr19:56810593-56810652 (-)	-1 bp
Tssr159886	Chr19:56810512-56810519 (-)	106 bp
Tssr159885	Chr19:56804250-56804252 (-)	6,371 bp
Tssr159884	Chr19:56804232-56804242 (-)	6,385 bp
Tssr159883	Chr19:56804216-56804230 (-)	6,399 bp
Tssr159882	Chr19:56804200-56804209 (-)	6,417 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24