Malt1 Gene Detail

Summary

• Symbol
  Malt1
• Name
  MALT1 paracaspase
• Synonyms
  D430033E09Rik, paracaspase, Pcasp1

• Feature Type
  protein coding gene
• IDs
  MGI:2445027
  NCBI Gene: 240354
• Alliance
  gene page
• Transcription Start Sites
  69 TSS

Location &
Maps

• Sequence Map
  Chr18:65564010-65612138 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 38.56 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  1239 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445027	protein coding gene	Chr18:65564009-65612138 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024508	protein coding gene	Chr18:65564672-65614340 (+)
A/J	MGP_AJ_G0024475	protein coding gene	Chr18:62722762-62770569 (+)
AKR/J	MGP_AKRJ_G0024445	protein coding gene	Chr18:64493258-64540952 (+)
BALB/cJ	MGP_BALBcJ_G0024474	protein coding gene	Chr18:62862314-62910618 (+)
C3H/HeJ	MGP_C3HHeJ_G0024242	protein coding gene	Chr18:64687444-64740064 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024921	protein coding gene	Chr18:67319113-67368314 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022352	protein coding gene	Chr18:62158737-62208656 (+)
CAST/EiJ	MGP_CASTEiJ_G0023715	protein coding gene	Chr18:64663995-64715636 (+)
CBA/J	MGP_CBAJ_G0024212	protein coding gene	Chr18:69515140-69567768 (+)
DBA/2J	MGP_DBA2J_G0024342	protein coding gene	Chr18:62375699-62425608 (+)
FVB/NJ	MGP_FVBNJ_G0024308	protein coding gene	Chr18:61770247-61817998 (+)
LP/J	MGP_LPJ_G0024426	protein coding gene	Chr18:65419890-65471029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024337	protein coding gene	Chr18:70944089-70996472 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024968	protein coding gene	Chr18:64702136-64750627 (+)
PWK/PhJ	MGP_PWKPhJ_G0023458	protein coding gene	Chr18:62631318-62680520 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023263	protein coding gene	Chr18:64849120-64899617 (+)
WSB/EiJ	MGP_WSBEiJ_G0023779	protein coding gene	Chr18:64554557-64604585 (+)

Homology

• Human Ortholog
  MALT1, MALT1 paracaspase

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MALT1, MALT1 paracaspase
  
• Synonyms
  IMD12, MLT, MLT1, PCASP1
• Links
  HGNC:6819

  NCBI Gene ID: 10892

  neXtProt AC: NX_Q9UDY8

  UniProt: Q9UDY8

  
  
• Chr Location
  18q21.32; chr18:58671465-58754477 (+)  GRCh38

---

• MGI Vertebrate Homology
  Malt1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MALT1
• Gene Tree
  Malt1
  

Human Diseases

• Diseases
  3 with human MALT1 associations

				Human Disease	Mouse Models
				immunodeficiency 12 IDs immunodeficiency 12       DOID:0111988 OMIM:615468 ORDO:397964
				lymphoma IDs lymphoma       DOID:0060058 DOID:1033 DOID:353 ICD10CM:C85.9 MESH:D008223 NCI:C3208 NCI:C7065 UMLS_CUI:C0024299 UMLS_CUI:C0598798
				non-Hodgkin lymphoma IDs non-Hodgkin lymphoma       DOID:0060060 ICD10CM:C85.9 MESH:D008228 NCI:C3211 OMIM:605027 ORDO:547 UMLS_CUI:C0024305

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 5 alleles in 5 genetic backgrounds
  8 phenotypes from multigenic genotypes
  58 phenotype references
  

• All Mutations and Alleles
  23
• Chemically induced (ENU)
  3
• Endonuclease-mediated
  4
• Gene trapped
  3
• Targeted
  13
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  35 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous inactivation of this gene disrupts normal B cell development and leads to impaired cytokine production and T cell and B cell proliferative responses after antigen receptor engagement due to failure of NF-kappaB activation.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  62
• GO References
  14

Expression

• Assay Results
  777
• Tissues
  10
• cDNA Data
  45
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase malt1

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  13
• UniProt
  5
• CCDS
  CCDS29306.1, CCDS89264.1

• Ensembl
  ENSMUSG00000032688 (Evidence)
• NCBI Gene
  240354

Representative Sequences			Length	Strain/Species
genomic	240354	NCBI Gene Model | MGI Sequence Detail	48129	C57BL/6J
transcript	NM_001365019	RefSeq | MGI Sequence Detail	5323	C57BL/6
polypeptide	Q2TBA3	UniProt | EBI | MGI Sequence Detail	832	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000010096 mucosa-associated lymphoid tissue lymphoma translocation protein 1
  (term hierarchy)
• PDB
  3V4L
• EC
  3.4.22.-
• InterPro Domains
  IPR029030 Caspase-like domain superfamily
  IPR052039 Caspase-related proteases and regulators
  IPR011029 Death-like domain superfamily
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2
  IPR037940 MALT1, death domain
  IPR041077 MALT1 immunoglobulin-like domain
  IPR033540 MALT1, immunoglobulin-like domain superfamily
  IPR011600 Peptidase C14, caspase domain
  IPR001309 Peptidase C14, p20 domain

Molecular
Reagents

• All nucleic 46

  cDNA 45

  Other 1

  
  

  Microarray probesets 2

References

• Summaries
  All 106

  Developmental Gene Expression 2

  Gene Ontology 14

  Phenotypes 58
• Earliest
  J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
• Latest
  J:337016 Wittner L, et al., Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int J Mol Sci. 2023 Apr 17;24(8)

TSS for Malt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151606	Chr18:65563179-65563182 (+)	-829 bp
Tssr151607	Chr18:65563688-65563715 (+)	-308 bp
Tssr151608	Chr18:65563840-65563853 (+)	-163 bp
Tssr151609	Chr18:65564016-65564044 (+)	20 bp
Tssr151610	Chr18:65564055-65564082 (+)	59 bp
Tssr151611	Chr18:65564083-65564108 (+)	86 bp
Tssr151612	Chr18:65564120-65564149 (+)	125 bp
Tssr151613	Chr18:65564153-65564158 (+)	146 bp
Tssr151614	Chr18:65564215-65564226 (+)	211 bp
Tssr151615	Chr18:65565140-65565153 (+)	1,137 bp
Tssr151616	Chr18:65568068-65568079 (+)	4,064 bp
Tssr151617	Chr18:65568358-65568371 (+)	4,355 bp
Tssr151618	Chr18:65569195-65569209 (+)	5,192 bp
Tssr151619	Chr18:65570450-65570462 (+)	6,446 bp
Tssr151620	Chr18:65570474-65570493 (+)	6,474 bp
Tssr151621	Chr18:65571257-65571279 (+)	7,258 bp
Tssr151622	Chr18:65571635-65571657 (+)	7,636 bp
Tssr151623	Chr18:65571730-65571744 (+)	7,727 bp
Tssr151624	Chr18:65571889-65571903 (+)	7,886 bp
Tssr151625	Chr18:65572611-65572633 (+)	8,612 bp
Tssr151626	Chr18:65574847-65574873 (+)	10,850 bp
Tssr151627	Chr18:65575286-65575298 (+)	11,282 bp
Tssr151628	Chr18:65575397-65575416 (+)	11,397 bp
Tssr151629	Chr18:65575435-65575451 (+)	11,433 bp
Tssr151630	Chr18:65575452-65575464 (+)	11,448 bp
Tssr151631	Chr18:65575660-65575676 (+)	11,658 bp
Tssr151632	Chr18:65577969-65577986 (+)	13,968 bp
Tssr151633	Chr18:65578637-65578646 (+)	14,632 bp
Tssr151634	Chr18:65579679-65579729 (+)	15,694 bp
Tssr151635	Chr18:65580676-65580708 (+)	16,682 bp
Tssr151636	Chr18:65580755-65580766 (+)	16,751 bp
Tssr151637	Chr18:65581245-65581271 (+)	17,248 bp
Tssr151638	Chr18:65581272-65581287 (+)	17,270 bp
Tssr151639	Chr18:65581340-65581366 (+)	17,343 bp
Tssr151640	Chr18:65582137-65582179 (+)	18,148 bp
Tssr151641	Chr18:65582976-65582998 (+)	18,977 bp
Tssr151642	Chr18:65583012-65583021 (+)	19,007 bp
Tssr151643	Chr18:65583769-65583780 (+)	19,765 bp
Tssr151644	Chr18:65586466-65586472 (+)	22,459 bp
Tssr151645	Chr18:65586765-65586785 (+)	22,765 bp
Tssr151646	Chr18:65586982-65587016 (+)	22,989 bp
Tssr151647	Chr18:65587064-65587081 (+)	23,063 bp
Tssr151648	Chr18:65587173-65587182 (+)	23,168 bp
Tssr151649	Chr18:65587243-65587256 (+)	23,240 bp
Tssr151650	Chr18:65587903-65587916 (+)	23,900 bp
Tssr151651	Chr18:65588929-65588953 (+)	24,931 bp
Tssr151652	Chr18:65589051-65589062 (+)	25,047 bp
Tssr151653	Chr18:65589269-65589280 (+)	25,265 bp
Tssr151654	Chr18:65589293-65589316 (+)	25,295 bp
Tssr151655	Chr18:65589520-65589530 (+)	25,515 bp
Tssr151656	Chr18:65591229-65591250 (+)	27,230 bp
Tssr151657	Chr18:65591438-65591451 (+)	27,435 bp
Tssr5354	Chr18:65592870-65592881 (+)	28,866 bp
Tssr151658	Chr18:65594087-65594101 (+)	30,084 bp
Tssr151659	Chr18:65594179-65594190 (+)	30,175 bp
Tssr151660	Chr18:65595820-65595831 (+)	31,816 bp
Tssr151661	Chr18:65595983-65595988 (+)	31,976 bp
Tssr151662	Chr18:65596345-65596383 (+)	32,354 bp
Tssr151663	Chr18:65597186-65597190 (+)	33,178 bp
Tssr151664	Chr18:65599014-65599041 (+)	35,018 bp
Tssr151665	Chr18:65599708-65599725 (+)	35,707 bp
Tssr151666	Chr18:65603547-65603563 (+)	39,545 bp
Tssr151670	Chr18:65609257-65609272 (+)	45,255 bp
Tssr151671	Chr18:65609376-65609406 (+)	45,381 bp
Tssr151672	Chr18:65609565-65609580 (+)	45,563 bp
Tssr151673	Chr18:65609588-65609601 (+)	45,585 bp
Tssr151674	Chr18:65609963-65609976 (+)	45,960 bp
Tssr151675	Chr18:65610170-65610177 (+)	46,164 bp
Tssr151676	Chr18:65611546-65611576 (+)	47,551 bp