Zc3h7a MGI Mouse Gene Detail - MGI:2445044 - zinc finger CCCH type containing 7 A

Symbol

Zc3h7a
Name

zinc finger CCCH type containing 7 A
Synonyms

A430104C18Rik, Zc3h7

Feature Type

protein coding gene
IDs

MGI:2445044
NCBI Gene: 106205
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:10954458-10994257 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 6.35 cM
Mapping Data

2 experiments

SNPs within 2kb

886 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445044	protein coding gene	Chr16:10954456-10994257 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022521	protein coding gene	Chr16:7987948-8032247 (-)
A/J	MGP_AJ_G0022483	protein coding gene	Chr16:7549992-7590346 (-)
AKR/J	MGP_AKRJ_G0022459	protein coding gene	Chr16:7900086-7941117 (-)
BALB/cJ	MGP_BALBcJ_G0022487	protein coding gene	Chr16:7690064-7730238 (-)
C3H/HeJ	MGP_C3HHeJ_G0022254	protein coding gene	Chr16:7976396-8017093 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022936	protein coding gene	Chr16:8154196-8196341 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020456	protein coding gene	Chr16:7708919-7748579 (-)
CAST/EiJ	MGP_CASTEiJ_G0021781	protein coding gene	Chr16:7999940-8043621 (-)
CBA/J	MGP_CBAJ_G0022223	protein coding gene	Chr16:8504815-8543796 (-)
DBA/2J	MGP_DBA2J_G0022354	protein coding gene	Chr16:7557402-7596410 (-)
FVB/NJ	MGP_FVBNJ_G0022330	protein coding gene	Chr16:7548838-7588675 (-)
LP/J	MGP_LPJ_G0022422	protein coding gene	Chr16:7944507-7984898 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022352	protein coding gene	Chr16:8196431-8242197 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0021521	protein coding gene	Chr16:7775522-7819159 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021351	protein coding gene	Chr16:7907959-7943098 (-)
WSB/EiJ	MGP_WSBEiJ_G0021829	protein coding gene	Chr16:7934710-7974897 (-)

Human Ortholog

ZC3H7A, zinc finger CCCH-type containing 7A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H7A, zinc finger CCCH-type containing 7A
Synonyms

HSPC055, ZC3H7, ZC3HDC7
Links

HGNC:30959

NCBI Gene ID: 29066

neXtProt AC: NX_Q8IWR0

UniProt: Q8IWR0
Chr Location

16p13.13; chr16:11750586-11797258 (-) GRCh38

MGI Vertebrate Homology

Zc3h7a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZC3H7A
Gene Tree

Zc3h7a

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

15
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

21
cDNA Data

171
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zc3h7a

ZFIN zc3h7a

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All Sequences

90
RefSeq

11
UniProt

14
CCDS

CCDS49762.1

Ensembl

ENSMUSG00000037965 (Evidence)
NCBI Gene

106205

			Length	Strain/Species	Flank
genomic	106205	NCBI Gene Model \| MGI Sequence Detail	39800	C57BL/6J	± kb
transcript	NR_027502	RefSeq \| MGI Sequence Detail	3795	C57BL/6
polypeptide	NP_666043	RefSeq \| MGI Sequence Detail	970	C57BL/6

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UniProt

14 Sequences
InterPro Domains

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR039691 Zinc finger CCCH domain-containing protein A/B

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily

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All nucleic 171

cDNA 171

Microarray probesets 4

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MGI:2146432, MGI:2146666

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zc3h7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140006	Chr16:10994134-10994229 (-)	75 bp
Tssr140005	Chr16:10994115-10994124 (-)	137 bp
Tssr140004	Chr16:10993920-10993934 (-)	330 bp
Tssr140003	Chr16:10993889-10993902 (-)	361 bp
Tssr140002	Chr16:10993385-10993435 (-)	847 bp
Tssr140001	Chr16:10972960-10972979 (-)	21,287 bp
Tssr140000	Chr16:10969595-10969629 (-)	24,645 bp
Tssr139999	Chr16:10967997-10968001 (-)	26,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24