Lacc1 MGI Mouse Gene Detail - MGI:2445077 - laccase domain containing 1

Symbol

Lacc1
Name

laccase domain containing 1
Synonyms

9030625A04Rik

Feature Type

protein coding gene
IDs

MGI:2445077
NCBI Gene: 210808
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr14:77261640-77274344 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 40.63 cM
Mapping Data

1 experiment

SNPs within 2kb

500 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445077	protein coding gene	Chr14:77261640-77274344 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021582	protein coding gene	Chr14:72008560-72029369 (-)
A/J	MGP_AJ_G0021540	protein coding gene	Chr14:70313398-70327735 (-)
AKR/J	MGP_AKRJ_G0021517	protein coding gene	Chr14:72406766-72419472 (-)
BALB/cJ	MGP_BALBcJ_G0021547	protein coding gene	Chr14:70116019-70129135 (-)
C3H/HeJ	MGP_C3HHeJ_G0021324	protein coding gene	Chr14:72122530-72135714 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021987	protein coding gene	Chr14:75120074-75134979 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019525	protein coding gene	Chr14:67902443-67917403 (-)
CAST/EiJ	MGP_CASTEiJ_G0020841	protein coding gene	Chr14:68863140-68878207 (-)
CBA/J	MGP_CBAJ_G0021292	protein coding gene	Chr14:77553259-77566098 (-)
DBA/2J	MGP_DBA2J_G0021415	protein coding gene	Chr14:69702300-69715672 (-)
FVB/NJ	MGP_FVBNJ_G0021393	protein coding gene	Chr14:69051216-69064400 (-)
LP/J	MGP_LPJ_G0021485	protein coding gene	Chr14:73142557-73157147 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021420	protein coding gene	Chr14:76208114-76221299 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022010	protein coding gene	Chr14:71690560-71704966 (-)
PWK/PhJ	MGP_PWKPhJ_G0020584	protein coding gene	Chr14:66485022-66498991 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020421	protein coding gene	Chr14:67674046-67689516 (-)
WSB/EiJ	MGP_WSBEiJ_G0020894	protein coding gene	Chr14:72038617-72051325 (-)

Human Ortholog

LACC1, laccase domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LACC1, laccase domain containing 1
Synonyms

C13orf31, FAMIN, JUVAR
Links

HGNC:26789

NCBI Gene ID: 144811

neXtProt AC: NX_Q8IV20

UniProt: Q8IV20
Chr Location

13q14.11; chr13:43879178-43893932 (+) GRCh38

MGI Vertebrate Homology

Lacc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LACC1
Gene Tree

Lacc1

Diseases

1 with human LACC1 associations

				Human Disease	Mouse Models
				juvenile rheumatoid arthritis IDs juvenile rheumatoid arthritis DOID:676 DOID:10129 DOID:1264 DOID:675 ICD10CM:M08.4 ICD9CM:714.3 ICD9CM:714.31 ICD9CM:714.32 ICD9CM:714.33 NCI:C26979 NCI:C61279 OMIM:604302 ORDO:92 UMLS_CUI:C0157916 UMLS_CUI:C0157917 UMLS_CUI:C0157918 UMLS_CUI:C0409667

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 5 alleles in 5 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

10
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Lacc1
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased fatty acid oxidation and glycolysis in macrophages and increased susceptibility to LPS-induced endotoxin shock.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lacc1

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All Sequences

43
RefSeq

6
UniProt

3
CCDS

CCDS27287.1

Ensembl

ENSMUSG00000044350 (Evidence)
NCBI Gene

210808

			Length	Strain/Species	Flank
genomic	210808	NCBI Gene Model \| MGI Sequence Detail	12705	C57BL/6J	± kb
transcript	NM_172488	RefSeq \| MGI Sequence Detail	2419	C57BL/6
polypeptide	Q8BZT9	UniProt \| EBI \| MGI Sequence Detail	430	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030799 purine nucleoside phosphorylase LACC1

(term hierarchy)
EC

2.4.2.1, 2.4.2.28, 3.5.4.4
InterPro Domains

IPR011324 Cytotoxic necrotizing factor-like, catalytic

IPR003730 Multi-copper polyphenol oxidoreductase

IPR038371 Multi-copper polyphenol oxidoreductase superfamily
GlyGen

Q8BZT9 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 20

Microarray probesets 4

Summaries

All 40

Gene Ontology 8

Phenotypes 16
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lacc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129839	Chr14:77274419-77274428 (-)	-80 bp
Tssr129838	Chr14:77274366-77274393 (-)	-36 bp
Tssr129837	Chr14:77274338-77274363 (-)	-7 bp
Tssr129836	Chr14:77274290-77274326 (-)	36 bp
Tssr129835	Chr14:77274056-77274133 (-)	249 bp
Tssr129834	Chr14:77274008-77274019 (-)	330 bp
Tssr129833	Chr14:77273992-77274001 (-)	347 bp
Tssr129832	Chr14:77270804-77270834 (-)	3,525 bp
Tssr129831	Chr14:77270790-77270801 (-)	3,548 bp
Tssr129830	Chr14:77270773-77270787 (-)	3,564 bp
Tssr129829	Chr14:77269943-77269956 (-)	4,394 bp
Tssr129828	Chr14:77269893-77269905 (-)	4,445 bp
Tssr129827	Chr14:77269229-77269249 (-)	5,105 bp
Tssr129826	Chr14:77267007-77267030 (-)	7,325 bp
Tssr129825	Chr14:77262375-77262390 (-)	11,961 bp
Tssr129824	Chr14:77261914-77261931 (-)	12,421 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24