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Nrros Gene Detail
Summary
  • Symbol
    Nrros
  • Name
    negative regulator of reactive oxygen species
  • Synonyms
    E430025L02Rik, Lrrc33
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445095
    NCBI Gene: 224109
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31961603-31984412 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445095
 protein coding gene Chr16:31961603-31984412 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022730
 protein coding gene Chr16:30182963-30207931 (-)
A/J MGP_AJ_G0022695
 protein coding gene Chr16:28774257-28791750 (-)
AKR/J MGP_AKRJ_G0022668
 protein coding gene Chr16:29823377-29840839 (-)
BALB/cJ MGP_BALBcJ_G0022697
 protein coding gene Chr16:28925509-28943166 (-)
C3H/HeJ MGP_C3HHeJ_G0022462
 protein coding gene Chr16:29948032-29966189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023146
 protein coding gene Chr16:30830989-30850875 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020664
 protein coding gene Chr16:29145330-29163086 (-)
CAST/EiJ MGP_CASTEiJ_G0021990
 protein coding gene Chr16:30073653-30094909 (-)
CBA/J MGP_CBAJ_G0022432
 protein coding gene Chr16:32081049-32100674 (-)
DBA/2J MGP_DBA2J_G0022565
 protein coding gene Chr16:28625714-28643296 (-)
FVB/NJ MGP_FVBNJ_G0022540
 protein coding gene Chr16:28608100-28625961 (-)
LP/J MGP_LPJ_G0022632
 protein coding gene Chr16:29971737-29994432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022559
 protein coding gene Chr16:31537755-31560322 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023158
 protein coding gene Chr16:29797279-29816057 (-)
PWK/PhJ MGP_PWKPhJ_G0021729
 protein coding gene Chr16:28943180-28961312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021560
 protein coding gene Chr16:29603400-29620483 (-)
WSB/EiJ MGP_WSBEiJ_G0022034
 protein coding gene Chr16:29736938-29757084 (-)



Homology
more
  • Human Ortholog
    NRROS, negative regulator of reactive oxygen species
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRROS, negative regulator of reactive oxygen species
  • Synonyms
    ELLP3030, GARPL1, LRRC33, SENEBAC, UNQ3030
  • Links
    NCBI Gene ID: 375387
    neXtProt AC: NX_Q86YC3
    UniProt: Q86YC3

  • Chr Location
    3q29; chr3:196639694-196662004 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to increased oxidative stress and susceptibility to experimental autoimmune encephalomyelitis, but to reduced susceptibility to bacterial infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    3
  • cDNA Data
    38
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 224109 NCBI Gene Model | MGI Sequence Detail 22810 C57BL/6J ±  kb
transcript NM_146069 RefSeq | MGI Sequence Detail 3723 C57BL/6  
polypeptide Q8BMT4 UniProt | EBI | MGI Sequence Detail 693 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000032507 transforming growth factor beta activator LRRC33
    (term hierarchy)
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
    IPR050328 Multifunctional Developmental and Immune Receptor
  • GlyGen
    Q8BMT4 11 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory