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Slfn9 Gene Detail
Summary
  • Symbol
    Slfn9
  • Name
    schlafen 9
  • Synonyms
    9830137M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445121
    NCBI Gene: 237886
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82869216-82882656 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445121
 protein coding gene Chr11:82865142-82883041 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018837
 protein coding gene Chr11:84269365-84288079 (-)
A/J MGP_AJ_G0018805
 protein coding gene Chr11:81078694-81098078 (-)
AKR/J MGP_AKRJ_G0018774
 protein coding gene Chr11:83470168-83486091 (-)
BALB/cJ MGP_BALBcJ_G0018777
 protein coding gene Chr11:81437436-81453236 (-)
C3H/HeJ MGP_C3HHeJ_G0018591
 protein coding gene Chr11:83493198-83506206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019229
 protein coding gene Chr11:86793831-86821206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016863
 protein coding gene Chr11:77991636-78176246 (-)
CAST/EiJ MGP_CASTEiJ_G0018147
 protein coding gene Chr11:84185060-84208174 (-)
CBA/J MGP_CBAJ_G0018562
 protein coding gene Chr11:90554917-90568424 (-)
DBA/2J MGP_DBA2J_G0018670
 protein coding gene Chr11:80608774-80620053 (-)
FVB/NJ MGP_FVBNJ_G0018660
 protein coding gene Chr11:80154130-80206434 (-)
LP/J MGP_LPJ_G0018740
 protein coding gene Chr11:84781466-84795337 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018686
 protein coding gene Chr11:90742117-90756644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019270
 protein coding gene Chr11:83789375-83793309 (-)
PWK/PhJ MGP_PWKPhJ_G0017916
 protein coding gene Chr11:81430278-81441515 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017707
 protein coding gene Chr11:83352647-83364873 (-)
WSB/EiJ MGP_WSBEiJ_G0018198
 protein coding gene Chr11:83609335-83623231 (-)



Homology
more
  • Human Ortholog
    SLFN11, schlafen family member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLFN11, schlafen family member 11
  • Synonyms
    SLFN8/9
  • Links
    NCBI Gene ID: 91607
    neXtProt AC: NX_Q7Z7L1
    UniProt: Q7Z7L1

  • Chr Location
    17q12; chr17:35350305-35373701 (-)  GRCh38
  • Human Ortholog
    SLFN13, schlafen family member 13
  • Synonyms
    hSLFN13, SLFN10
  • Links
    NCBI Gene ID: 146857
    neXtProt AC: NX_Q68D06
    UniProt: Q68D06

  • Chr Location
    17q12; chr17:35435096-35449766 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    2
  • Targeted
    4
  • Genomic Mutations
    2 involving Slfn9
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    41 strains or lines available
Homozygous null mice show resistance to CGT-motif containing ssDNA-induced inflammation, acute hepatitis, and septic shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069793 Ensembl Gene Model | MGI Sequence Detail 13441 C57BL/6J ±  kb
transcript ENSMUST00000038211 Ensembl | MGI Sequence Detail 5769 Not Applicable  
polypeptide ENSMUSP00000044435 Ensembl | MGI Sequence Detail 910 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.-.-
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain
    IPR007421 Schlafen, AlbA_2 domain
    IPR038461 Schlafen, AlbA_2 domain superfamily
    IPR029684 Schlafen family
    IPR018647 Schlafen group 3-like, DNA/RNA helicase domain
    IPR048729 Schlafen, GTPase-like domain
    IPR027785 UvrD-like helicase C-terminal domain
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:351319 Zhang P, et al., Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA. Sci Immunol. 2024 Jun 14;9(96):eadj5465
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory