Wdr41 MGI Mouse Gene Detail - MGI:2445123

Symbol

Wdr41
Name

WD repeat domain 41
Synonyms

B830029I03Rik, MSTP048

Feature Type

protein coding gene
IDs

MGI:2445123
NCBI Gene: 218460
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:95112852-95159821 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 49.22 cM
Mapping Data

2 experiments

SNPs within 2kb

1624 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445123	protein coding gene	Chr13:95112226-95161800 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020836	protein coding gene	Chr13:96416701-96467758 (+)
A/J	MGP_AJ_G0020790	protein coding gene	Chr13:92804937-92852328 (+)
AKR/J	MGP_AKRJ_G0020764	protein coding gene	Chr13:95642174-95689023 (+)
BALB/cJ	MGP_BALBcJ_G0020787	protein coding gene	Chr13:93485492-93532681 (+)
C3H/HeJ	MGP_C3HHeJ_G0020580	protein coding gene	Chr13:95337440-95384256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021223	protein coding gene	Chr13:99348451-99396140 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018792	protein coding gene	Chr13:88643447-88689147 (+)
CAST/EiJ	MGP_CASTEiJ_G0020099	protein coding gene	Chr13:94618653-94669656 (+)
CBA/J	MGP_CBAJ_G0020539	protein coding gene	Chr13:103291644-103346533 (+)
DBA/2J	MGP_DBA2J_G0020664	protein coding gene	Chr13:92591421-92638070 (+)
FVB/NJ	MGP_FVBNJ_G0020645	protein coding gene	Chr13:91378207-91424804 (+)
LP/J	MGP_LPJ_G0020739	protein coding gene	Chr13:96522093-96572439 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020673	protein coding gene	Chr13:103746433-103795652 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021263	protein coding gene	Chr13:95042515-95089265 (+)
PWK/PhJ	MGP_PWKPhJ_G0019851	protein coding gene	Chr13:91331177-91378366 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019675	protein coding gene	Chr13:91318577-91372045 (+)
WSB/EiJ	MGP_WSBEiJ_G0020156	protein coding gene	Chr13:95538596-95586216 (+)

Human Ortholog

WDR41, WD repeat domain 41

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDR41, WD repeat domain 41
Synonyms

MSTP048
Links

HGNC:25601

NCBI Gene ID: 55255

neXtProt AC: NX_Q9HAD4

UniProt: Q9HAD4
Chr Location

5q13.3-q14.1; chr5:77425970-77620611 (-) GRCh38

MGI Vertebrate Homology

Wdr41 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDR41
Gene Tree

Wdr41

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Wdr41
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-generated allele exhibit increased susceptibility to DDS-induced colitis with increased activated single positive T cells.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdr41

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All Sequences

55
RefSeq

7
UniProt

3
CCDS

CCDS56896.2

Ensembl

ENSMUSG00000042015 (Evidence)
NCBI Gene

218460

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042015	Ensembl Gene Model \| MGI Sequence Detail	46970	C57BL/6J	± kb
transcript	ENSMUST00000160115	Ensembl \| MGI Sequence Detail	2851	Not Applicable
polypeptide	ENSMUSP00000138543	Ensembl \| MGI Sequence Detail	467	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031118 WD repeat-containing protein 41

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR011004 Trimeric LpxA-like superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR040102 WD repeat-containing protein 41

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All nucleic 35

cDNA 35

Microarray probesets 3

Summaries

All 36

Gene Ontology 6

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wdr41:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120705	Chr13:95112872-95112930 (+)	49 bp
Tssr120706	Chr13:95112943-95112960 (+)	100 bp
Tssr120707	Chr13:95112963-95112983 (+)	121 bp
Tssr120708	Chr13:95146490-95146498 (+)	33,642 bp
Tssr120709	Chr13:95146518-95146536 (+)	33,675 bp
Tssr120710	Chr13:95158334-95158371 (+)	45,501 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24