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Enpp6 Gene Detail
Summary
  • Symbol
    Enpp6
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 6
  • Synonyms
    4833421B01Rik, B830047L21Rik, D8Ertd514e, Npp6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445171
    NCBI Gene: 320981
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:47439922-47549797 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3801 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445171
 protein coding gene Chr8:47439920-47549797 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033593
 protein coding gene Chr8:46140569-46241953 (+)
A/J MGP_AJ_G0033575
 protein coding gene Chr8:44341648-44443147 (+)
AKR/J MGP_AKRJ_G0033500
 protein coding gene Chr8:45630705-45735121 (+)
BALB/cJ MGP_BALBcJ_G0033572
 protein coding gene Chr8:44515575-44618336 (+)
C3H/HeJ MGP_C3HHeJ_G0033281
 protein coding gene Chr8:46168345-46277078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034088
 protein coding gene Chr8:47859886-47977327 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031037
 protein coding gene Chr8:40585329-40687457 (+)
CAST/EiJ MGP_CASTEiJ_G0032607
 protein coding gene Chr8:45626447-45737587 (+)
CBA/J MGP_CBAJ_G0033260
 protein coding gene Chr8:49799618-49913572 (+)
DBA/2J MGP_DBA2J_G0033413
 protein coding gene Chr8:44135017-44241136 (+)
FVB/NJ MGP_FVBNJ_G0033354
 protein coding gene Chr8:43610362-43716656 (+)
LP/J MGP_LPJ_G0033501
 protein coding gene Chr8:46141006-46248693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033399
 protein coding gene Chr8:49843738-49954788 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034106
 protein coding gene Chr8:45810341-45918627 (+)
PWK/PhJ MGP_PWKPhJ_G0032315
 protein coding gene Chr8:43666735-43817580 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032151
 protein coding gene Chr8:44975982-45082408 (+)
WSB/EiJ MGP_WSBEiJ_G0032723
 protein coding gene Chr8:46061882-46170642 (+)



Homology
more
  • Human Ortholog
    ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase 6
  • Synonyms
    NPP6
  • Links
    NCBI Gene ID: 133121
    neXtProt AC: NX_Q6UWR7
    UniProt: Q6UWR7

  • Chr Location
    4q35.1; chr4:184088706-184221230 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038173 Ensembl Gene Model | MGI Sequence Detail 109876 C57BL/6J ±  kb
transcript ENSMUST00000039840 Ensembl | MGI Sequence Detail 4970 Not Applicable  
polypeptide ENSMUSP00000044608 Ensembl | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007090 glycerophosphocholine cholinephosphodiesterase ENPP6
    (term hierarchy)
  • PDB
    5EGE, 5EGH
  • EC
    3.1.4.-, 3.1.4.38
  • InterPro Domains
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
  • GlyGen
    Q8BGN3 6 sites, 7 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 17
    Primer pair 3
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:1261759, MGI:1921014
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory