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Cd109 Gene Detail
Summary
  • Symbol
    Cd109
  • Name
    CD109 antigen
  • Synonyms
    9930012E15Rik, Gov platelet alloantigens
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445221
    NCBI Gene: 235505
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78522828-78623535 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445221
 protein coding gene Chr9:78522828-78623542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035073
 protein coding gene Chr9:79136785-79238876 (+)
A/J MGP_AJ_G0035054
 protein coding gene Chr9:76396152-76499467 (+)
AKR/J MGP_AKRJ_G0034982
 protein coding gene Chr9:78215190-78314622 (+)
BALB/cJ MGP_BALBcJ_G0035042
 protein coding gene Chr9:76056316-76158196 (+)
C3H/HeJ MGP_C3HHeJ_G0034754
 protein coding gene Chr9:78710920-78815165 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035565
 protein coding gene Chr9:81271566-81388680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032472
 protein coding gene Chr9:75615788-75719473 (+)
CAST/EiJ MGP_CASTEiJ_G0034072
 protein coding gene Chr9:79020806-79131510 (+)
CBA/J MGP_CBAJ_G0034727
 protein coding gene Chr9:84151232-84256982 (+)
DBA/2J MGP_DBA2J_G0034885
 protein coding gene Chr9:76044954-76146890 (+)
FVB/NJ MGP_FVBNJ_G0034828
 protein coding gene Chr9:75263557-75369385 (+)
LP/J MGP_LPJ_G0034966
 protein coding gene Chr9:79353417-79471248 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034870
 protein coding gene Chr9:85335145-85442026 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035586
 protein coding gene Chr9:78380489-78482547 (+)
PWK/PhJ MGP_PWKPhJ_G0033775
 protein coding gene Chr9:76233535-76339578 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033612
 protein coding gene Chr9:78571958-78672273 (+)
WSB/EiJ MGP_WSBEiJ_G0034189
 protein coding gene Chr9:78322854-78426230 (+)



Homology
more
  • Human Ortholog
    CD109, CD109 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD109, CD109 molecule
  • Synonyms
    CPAMD7, p180, r150
  • Links
    NCBI Gene ID: 135228
    neXtProt AC: NX_Q6YHK3
    UniProt: Q6YHK3

  • Chr Location
    6q13; chr6:73679192-73828316 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display epidermal hyperplasia and thickening, sebaceous gland hyperplasia and transient impairment of hair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    10
  • cDNA Data
    43
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046186 Ensembl Gene Model | MGI Sequence Detail 100708 C57BL/6J ±  kb
    transcript ENSMUST00000093812 Ensembl | MGI Sequence Detail 5860 Not Applicable  
    polypeptide ENSMUSP00000091330 Ensembl | MGI Sequence Detail 1442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001296 CD109 molecule
      (term hierarchy)
    • InterPro Domains
      IPR001599 Alpha-2-macroglobulin
      IPR011625 Alpha-2-macroglobulin, bait region domain
      IPR050473 Alpha-2-macroglobulin/Complement system
      IPR019742 Alpha-2-macroglobulin, conserved site
      IPR041813 Alpha-2-macroglobulin, TED domain
      IPR011626 Alpha-macroglobulin-like, TED domain
      IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
      IPR009048 Alpha-macroglobulin, receptor-binding
      IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002890 Macroglobulin domain
      IPR041555 Macroglobulin domain MG3
      IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    • GlyGen
      Q8R422 10 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143078
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory