Fam120a MGI Mouse Gene Detail - MGI:2446163 - family with sequence similarity 120, member A

Symbol

Fam120a
Name

family with sequence similarity 120, member A

Feature Type

protein coding gene
IDs

MGI:2446163
NCBI Gene: 218236
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr13:49032695-49121493 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.00 cM
Mapping Data

1 experiment

SNPs within 2kb

1414 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446163	protein coding gene	Chr13:49032692-49121754 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020528	protein coding gene	Chr13:47821167-47916882 (-)
A/J	MGP_AJ_G0020482	protein coding gene	Chr13:46127647-46219340 (-)
AKR/J	MGP_AKRJ_G0020459	protein coding gene	Chr13:47424718-47516778 (-)
BALB/cJ	MGP_BALBcJ_G0020478	protein coding gene	Chr13:46343747-46434505 (-)
C3H/HeJ	MGP_C3HHeJ_G0020277	protein coding gene	Chr13:47251473-47344705 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020911	protein coding gene	Chr13:49263226-49361093 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018496	protein coding gene	Chr13:44119570-44205289 (-)
CAST/EiJ	MGP_CASTEiJ_G0019792	protein coding gene	Chr13:47258340-47349515 (-)
CBA/J	MGP_CBAJ_G0020238	protein coding gene	Chr13:51309693-51411580 (-)
DBA/2J	MGP_DBA2J_G0020360	protein coding gene	Chr13:45655583-45746077 (-)
FVB/NJ	MGP_FVBNJ_G0020339	protein coding gene	Chr13:45168220-45257951 (-)
LP/J	MGP_LPJ_G0020435	protein coding gene	Chr13:48044045-48139856 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020368	protein coding gene	Chr13:51039419-51136457 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020954	protein coding gene	Chr13:47130635-47223798 (-)
PWK/PhJ	MGP_PWKPhJ_G0019548	protein coding gene	Chr13:45822884-45915765 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019376	protein coding gene	Chr13:45836040-45924484 (-)
WSB/EiJ	MGP_WSBEiJ_G0019854	protein coding gene	Chr13:47439507-47531702 (-)

Human Ortholog

FAM120A, family with sequence similarity 120 member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM120A, family with sequence similarity 120 member A
Synonyms

C9orf10, HBVPTPAP, OSSA
Links

HGNC:13247

NCBI Gene ID: 23196

neXtProt AC: NX_Q9NZB2

UniProt: Q9NZB2
Chr Location

9q22.31; chr9:93451685-93566112 (+) GRCh38

MGI Vertebrate Homology

Fam120a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM120A
Gene Tree

Fam120a

less

Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

16
Genomic Mutations

1 involving Fam120a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

25
cDNA Data

200
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam120a

ZFIN fam120a

less

All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS49259.1

Ensembl

ENSMUSG00000038014 (Evidence)
NCBI Gene

218236

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038014	Ensembl Gene Model \| MGI Sequence Detail	88799	C57BL/6J	± kb
transcript	ENSMUST00000060805	Ensembl \| MGI Sequence Detail	5105	Not Applicable
polypeptide	ENSMUSP00000053877	Ensembl \| MGI Sequence Detail	1112	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000032357 constitutive coactivator of PPAR-gamma-like protein 1

(term hierarchy)
InterPro Domains

IPR026784 Constitutive coactivator of PPAR-gamma

IPR029060 PIN-like domain superfamily
GlyGen

Q6A0A9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

less

All nucleic 201

cDNA 201

Microarray probesets 6

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam120a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122429	Chr13:49122232-49122235 (-)	-741 bp
Tssr122428	Chr13:49121954-49121965 (-)	-467 bp
Tssr122427	Chr13:49121897-49121942 (-)	-427 bp
Tssr4063	Chr13:49121752-49121762 (-)	-264 bp
Tssr4062	Chr13:49121712-49121727 (-)	-227 bp
Tssr122426	Chr13:49121685-49121696 (-)	-198 bp
Tssr122425	Chr13:49121591-49121600 (-)	-103 bp
Tssr122424	Chr13:49121553-49121558 (-)	-63 bp
Tssr122423	Chr13:49121510-49121544 (-)	-34 bp
Tssr122422	Chr13:49121480-49121505 (-)	0 bp
Tssr122421	Chr13:49102617-49102633 (-)	18,868 bp
Tssr122420	Chr13:49088604-49088614 (-)	32,884 bp
Tssr122419	Chr13:49075675-49075694 (-)	45,808 bp
Tssr122418	Chr13:49034148-49034165 (-)	87,336 bp
Tssr122417	Chr13:49033915-49033931 (-)	87,570 bp
Tssr122416	Chr13:49033782-49033804 (-)	87,700 bp
Tssr122415	Chr13:49033618-49033623 (-)	87,872 bp
Tssr122414	Chr13:49033489-49033528 (-)	87,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24