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Kdm4a Gene Detail
Summary
  • Symbol
    Kdm4a
  • Name
    lysine (K)-specific demethylase 4A
  • Synonyms
    D4Ertd222e, JHDM3A, Jmjd2, Jmjd2a, MGC:28562, mKIAA0677
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446210
    NCBI Gene: 230674
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117994154-118037216 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1247 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446210
 protein coding gene Chr4:117994154-118037240 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028663
 protein coding gene Chr4:119163791-119208091 (-)
A/J MGP_AJ_G0028624
 protein coding gene Chr4:114562856-114607460 (-)
AKR/J MGP_AKRJ_G0028574
 protein coding gene Chr4:117070578-117114248 (-)
BALB/cJ MGP_BALBcJ_G0028645
 protein coding gene Chr4:115194746-115240994 (-)
C3H/HeJ MGP_C3HHeJ_G0028359
 protein coding gene Chr4:118639817-118685473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029086
 protein coding gene Chr4:123738891-123786387 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026370
 protein coding gene Chr4:108584739-108629936 (-)
CAST/EiJ MGP_CASTEiJ_G0027793
 protein coding gene Chr4:115886880-115933086 (-)
CBA/J MGP_CBAJ_G0028326
 protein coding gene Chr4:127116468-127174070 (-)
DBA/2J MGP_DBA2J_G0028474
 protein coding gene Chr4:115174387-115216862 (-)
FVB/NJ MGP_FVBNJ_G0028442
 protein coding gene Chr4:113688893-113735085 (-)
LP/J MGP_LPJ_G0028576
 protein coding gene Chr4:119348608-119393564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028469
 protein coding gene Chr4:132037890-132082959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029123
 protein coding gene Chr4:118229134-118271838 (-)
PWK/PhJ MGP_PWKPhJ_G0027519
 protein coding gene Chr4:112004134-112046349 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027342
 protein coding gene Chr4:114529321-114573619 (-)
WSB/EiJ MGP_WSBEiJ_G0027872
 protein coding gene Chr4:118102405-118147876 (-)



Homology
more
  • Human Ortholog
    KDM4A, lysine demethylase 4A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM4A, lysine demethylase 4A
  • Synonyms
    JHDM3A, JMJD2, JMJD2A, TDRD14A
  • Links
    NCBI Gene ID: 9682
    neXtProt AC: NX_O75164
    UniProt: O75164

  • Chr Location
    1p34.2-p34.1; chr1:43650149-43705518 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    47
  • cDNA Data
    59
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230674 NCBI Gene Model | MGI Sequence Detail 43063 C57BL/6J ±  kb
    transcript NR_189679 RefSeq | MGI Sequence Detail 5129 C57BL/6  
    polypeptide Q8BW72 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 59
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1098782
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:339780 Nishimura H, et al., Maternal epigenetic factors in embryonic and postnatal development. Genes Cells. 2023 Jun;28(6):422-432
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory