Themis2 MGI Mouse Gene Detail - MGI:2446213 - thymocyte selection associated family member 2

Symbol

Themis2
Name

thymocyte selection associated family member 2
Synonyms

BC013712, ICB-1

Feature Type

protein coding gene
IDs

MGI:2446213
NCBI Gene: 230787
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:132509148-132523675 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.90 cM
Mapping Data

1 experiment

SNPs within 2kb

474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446213	protein coding gene	Chr4:132509148-132523698 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028880	protein coding gene	Chr4:134970138-134986968 (-)
A/J	MGP_AJ_G0028839	protein coding gene	Chr4:129347888-129365351 (-)
AKR/J	MGP_AKRJ_G0028792	protein coding gene	Chr4:132995118-133010605 (-)
BALB/cJ	MGP_BALBcJ_G0028862	protein coding gene	Chr4:129966616-129981465 (-)
C3H/HeJ	MGP_C3HHeJ_G0028576	protein coding gene	Chr4:133255283-133271491 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029304	protein coding gene	Chr4:139841486-139857292 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026575	protein coding gene	Chr4:122423851-122436871 (-)
CAST/EiJ	MGP_CASTEiJ_G0028009	protein coding gene	Chr4:131327092-131344366 (-)
CBA/J	MGP_CBAJ_G0028542	protein coding gene	Chr4:143423800-143441885 (-)
DBA/2J	MGP_DBA2J_G0028691	protein coding gene	Chr4:129767915-129783181 (-)
FVB/NJ	MGP_FVBNJ_G0028658	protein coding gene	Chr4:128629888-128644550 (-)
LP/J	MGP_LPJ_G0028792	protein coding gene	Chr4:135116841-135132071 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028684	protein coding gene	Chr4:148011436-148029122 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029342	protein coding gene	Chr4:133413566-133430563 (-)
PWK/PhJ	MGP_PWKPhJ_G0027730	protein coding gene	Chr4:126466580-126481514 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027556	protein coding gene	Chr4:129254176-129268066 (-)
WSB/EiJ	MGP_WSBEiJ_G0028089	protein coding gene	Chr4:133584884-133599498 (-)

Human Ortholog

THEMIS2, thymocyte selection associated family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THEMIS2, thymocyte selection associated family member 2
Synonyms

C1orf38, ICB-1, ICB1
Links

HGNC:16839

NCBI Gene ID: 9473

neXtProt AC: NX_Q5TEJ8

UniProt: Q5TEJ8
Chr Location

1p35.3; chr1:27872543-27886685 (+) GRCh38

MGI Vertebrate Homology

Themis2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THEMIS2
Gene Tree

Themis2

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Themis2
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal B cell development, activation, and antibody responses.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

33

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

1
CCDS

CCDS18735.1

Ensembl

ENSMUSG00000037731 (Evidence)
NCBI Gene

230787

			Length	Strain/Species	Flank
genomic	230787	NCBI Gene Model \| MGI Sequence Detail	14528	C57BL/6J	± kb
transcript	NM_001033308	RefSeq \| MGI Sequence Detail	2542	C57BL/6
polypeptide	Q91YX0	UniProt \| EBI \| MGI Sequence Detail	663	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008881 induced by contact to basement membrane 1 protein

(term hierarchy)
InterPro Domains

IPR025946 CABIT domain

IPR039671 Protein THEMIS

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All nucleic 33

cDNA 33

Microarray probesets 3

Summaries

All 37

Gene Ontology 4

Phenotypes 11
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Themis2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1324	Chr4:132523706-132523728 (-)	-42 bp
Tssr43717	Chr4:132523672-132523700 (-)	-11 bp
Tssr43716	Chr4:132521413-132521423 (-)	2,257 bp
Tssr43715	Chr4:132518189-132518195 (-)	5,483 bp
Tssr43714	Chr4:132517206-132517222 (-)	6,461 bp
Tssr43713	Chr4:132512780-132512789 (-)	10,890 bp
Tssr43712	Chr4:132512679-132512692 (-)	10,989 bp
Tssr43711	Chr4:132512562-132512602 (-)	11,093 bp
Tssr43710	Chr4:132511259-132511276 (-)	12,407 bp
Tssr43709	Chr4:132510784-132510812 (-)	12,877 bp
Tssr43708	Chr4:132510749-132510765 (-)	12,918 bp
Tssr43707	Chr4:132509785-132509798 (-)	13,883 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24