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Sh2d5 Gene Detail
Summary
  • Symbol
    Sh2d5
  • Name
    SH2 domain containing 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446215
    NCBI Gene: 230863
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137977722-137988279 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446215
 protein coding gene Chr4:137977714-137988643 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028991
 protein coding gene Chr4:140965942-140981035 (+)
A/J MGP_AJ_G0028950
 protein coding gene Chr4:134949516-134960458 (+)
AKR/J MGP_AKRJ_G0028902
 protein coding gene Chr4:138798797-138809726 (+)
BALB/cJ MGP_BALBcJ_G0028974
 protein coding gene Chr4:135621323-135633689 (+)
C3H/HeJ MGP_C3HHeJ_G0028688
 protein coding gene Chr4:139157977-139170989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029415
 protein coding gene Chr4:145974259-145985189 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026686
 protein coding gene Chr4:127932591-127943719 (+)
CAST/EiJ MGP_CASTEiJ_G0028120
 protein coding gene Chr4:137313773-137324739 (+)
CBA/J MGP_CBAJ_G0028653
 protein coding gene Chr4:150129852-150140783 (+)
DBA/2J MGP_DBA2J_G0028802
 protein coding gene Chr4:135323521-135337670 (+)
FVB/NJ MGP_FVBNJ_G0028769
 protein coding gene Chr4:134348046-134358817 (+)
LP/J MGP_LPJ_G0028901
 protein coding gene Chr4:141053486-141064415 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028795
 protein coding gene Chr4:154148437-154160596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029453
 protein coding gene Chr4:139309377-139321129 (+)
PWK/PhJ MGP_PWKPhJ_G0027840
 protein coding gene Chr4:132173120-132184758 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027666
 protein coding gene Chr4:135087864-135098761 (+)
WSB/EiJ MGP_WSBEiJ_G0028198
 protein coding gene Chr4:139541400-139552351 (+)



Homology
more
  • Human Ortholog
    SH2D5, SH2 domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH2D5, SH2 domain containing 5
  • Links
    NCBI Gene ID: 400745
    neXtProt AC: NX_Q6ZV89
    UniProt: Q6ZV89

  • Chr Location
    1p36.12; chr1:20719731-20732837 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230863 NCBI Gene Model | MGI Sequence Detail 10558 C57BL/6J ±  kb
    transcript NM_001099631 RefSeq | MGI Sequence Detail 3095 C57BL/6  
    polypeptide Q8JZW5 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory