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Tet3 Gene Detail
Summary
  • Symbol
    Tet3
  • Name
    tet methylcytosine dioxygenase 3
  • Synonyms
    B430006D22Rik, D230004J03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446229
    NCBI Gene: 194388
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83339355-83434190 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2071 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446229
 protein coding gene Chr6:83339355-83436066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030931
 protein coding gene Chr6:84373927-84464598 (-)
A/J MGP_AJ_G0030900
 protein coding gene Chr6:81162795-81254184 (-)
AKR/J MGP_AKRJ_G0030828
 protein coding gene Chr6:83516955-83607791 (-)
BALB/cJ MGP_BALBcJ_G0030910
 protein coding gene Chr6:81182029-81278768 (-)
C3H/HeJ MGP_C3HHeJ_G0030800
 protein coding gene Chr6:100781634-100874516 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031370
 protein coding gene Chr6:86687569-86790784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028556
 protein coding gene Chr6:79507947-79607831 (-)
CAST/EiJ MGP_CASTEiJ_G0030019
 protein coding gene Chr6:83529447-83624214 (-)
CBA/J MGP_CBAJ_G0030597
 protein coding gene Chr6:90098192-90194245 (-)
DBA/2J MGP_DBA2J_G0030750
 protein coding gene Chr6:80479013-80571968 (-)
FVB/NJ MGP_FVBNJ_G0030703
 protein coding gene Chr6:79687208-79779665 (-)
LP/J MGP_LPJ_G0030829
 protein coding gene Chr6:84380643-84474348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030739
 protein coding gene Chr6:94401864-94504651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031394
 protein coding gene Chr6:83319004-83413878 (-)
PWK/PhJ MGP_PWKPhJ_G0029734
 protein coding gene Chr6:79376338-79475754 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029562
 protein coding gene Chr6:82171093-82267343 (-)
WSB/EiJ MGP_WSBEiJ_G0030100
 protein coding gene Chr6:83750459-83853836 (-)



Homology
more
  • Human Ortholog
    TET3, tet methylcytosine dioxygenase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TET3, tet methylcytosine dioxygenase 3
  • Synonyms
    BEFAHRS, hCG_40738
  • Links
    NCBI Gene ID: 200424
    neXtProt AC: NX_O43151
    UniProt: O43151

  • Chr Location
    2p13.1; chr2:73983631-74135498 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice inheriting a null allele from a germ cell conditional null mother display impaired reprogramming of the paternal genome resulting in reduced embryo viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    157
  • cDNA Data
    11
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 194388 NCBI Gene Model | MGI Sequence Detail 94836 C57BL/6J ±  kb
    transcript NM_001347313 RefSeq | MGI Sequence Detail 11613 C57BL/6  
    polypeptide Q8BG87 UniProt | EBI | MGI Sequence Detail 1803 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 12
      Primer pair 8
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2444739
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 34
      Gene Ontology 16
      Phenotypes 52
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:359295 Gioulbasani M, et al., Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice. Commun Biol. 2024 Dec 3;7(1):1606
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory