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Vps33b Gene Detail
Summary
  • Symbol
    Vps33b
  • Name
    vacuolar protein sorting 33B
  • Synonyms
    MGC:36556
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446237
    NCBI Gene: 233405
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79919369-79941323 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    787 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446237
 protein coding gene Chr7:79919369-79941502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032408
 protein coding gene Chr7:82239259-82261317 (+)
A/J MGP_AJ_G0032387
 protein coding gene Chr7:80312778-80334970 (+)
AKR/J MGP_AKRJ_G0032323
 protein coding gene Chr7:82050664-82072846 (+)
BALB/cJ MGP_BALBcJ_G0032399
 protein coding gene Chr7:79989501-80011739 (+)
C3H/HeJ MGP_C3HHeJ_G0032112
 protein coding gene Chr7:82699331-82722535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032891
 protein coding gene Chr7:85458590-85481569 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029899
 protein coding gene Chr7:82832181-82855251 (+)
CAST/EiJ MGP_CASTEiJ_G0031440
 protein coding gene Chr7:73585385-73607274 (+)
CBA/J MGP_CBAJ_G0032078
 protein coding gene Chr7:88308828-88332403 (+)
DBA/2J MGP_DBA2J_G0032233
 protein coding gene Chr7:78871777-78893760 (+)
FVB/NJ MGP_FVBNJ_G0032188
 protein coding gene Chr7:78784370-78806511 (+)
LP/J MGP_LPJ_G0032314
 protein coding gene Chr7:83477209-83499319 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032225
 protein coding gene Chr7:88465627-88489002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032909
 protein coding gene Chr7:81483039-81506699 (+)
PWK/PhJ MGP_PWKPhJ_G0031160
 protein coding gene Chr7:72055748-72078662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031001
 protein coding gene Chr7:68490190-68513808 (+)
WSB/EiJ MGP_WSBEiJ_G0031558
 protein coding gene Chr7:81839061-81861204 (+)



Homology
more
  • Human Ortholog
    VPS33B, VPS33B late endosome and lysosome associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS33B, VPS33B late endosome and lysosome associated
  • Synonyms
    KDIDAR, PFIC12
  • Links
    NCBI Gene ID: 26276
    neXtProt AC: NX_Q9H267
    UniProt: Q9H267

  • Chr Location
    15q26.1; chr15:90998416-91022621 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vps33b mouse models; 5 with human VPS33B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated by an inducible cre exhibit dry scaly skin, hair loss, thrombocytosis, abnormal alpha-granule development, extramedullary hematopoiesis, abnormal platelets and megakaryocytes, and defects in tail tendon collagen I structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    5
  • cDNA Data
    26
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233405 NCBI Gene Model | MGI Sequence Detail 21955 C57BL/6J ±  kb
    transcript NM_001420428 RefSeq | MGI Sequence Detail 2602 C57BL/6  
    polypeptide P59016 UniProt | EBI | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 2
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory