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Edc4 Gene Detail
Summary
  • Symbol
    Edc4
  • Name
    enhancer of mRNA decapping 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446249
    NCBI Gene: 234699
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106607506-106619857 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446249
 protein coding gene Chr8:106607506-106621540 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034064
 protein coding gene Chr8:108201112-108215139 (+)
A/J MGP_AJ_G0034045
 protein coding gene Chr8:103874090-103888117 (+)
AKR/J MGP_AKRJ_G0033971
 protein coding gene Chr8:106876455-106890482 (+)
BALB/cJ MGP_BALBcJ_G0034038
 protein coding gene Chr8:104060744-104074771 (+)
C3H/HeJ MGP_C3HHeJ_G0033750
 protein coding gene Chr8:107618788-107632815 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034558
 protein coding gene Chr8:112174396-112188423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031500
 protein coding gene Chr8:97014893-97027825 (+)
CAST/EiJ MGP_CASTEiJ_G0033076
 protein coding gene Chr8:107137271-107151323 (+)
CBA/J MGP_CBAJ_G0033723
 protein coding gene Chr8:115775644-115789671 (+)
DBA/2J MGP_DBA2J_G0033878
 protein coding gene Chr8:103219871-103234116 (+)
FVB/NJ MGP_FVBNJ_G0033823
 protein coding gene Chr8:102152705-102166725 (+)
LP/J MGP_LPJ_G0033969
 protein coding gene Chr8:108413516-108427543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033867
 protein coding gene Chr8:118971778-118985805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034576
 protein coding gene Chr8:106842442-106856469 (+)
PWK/PhJ MGP_PWKPhJ_G0032777
 protein coding gene Chr8:102622836-102637018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032618
 protein coding gene Chr8:105535154-105549057 (+)
WSB/EiJ MGP_WSBEiJ_G0033192
 protein coding gene Chr8:107530589-107544640 (+)



Homology
more
  • Human Ortholog
    EDC4, enhancer of mRNA decapping 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDC4, enhancer of mRNA decapping 4
  • Synonyms
    Ge-1, GE1, HEDL5, HEDLS, RCD-8, RCD8
  • Links
    NCBI Gene ID: 23644
    neXtProt AC: NX_Q6P2E9
    UniProt: Q6P2E9

  • Chr Location
    16q22.1; chr16:67873052-67884499 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    10
  • cDNA Data
    123
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 234699 NCBI Gene Model | MGI Sequence Detail 12352 C57BL/6J ±  kb
transcript NM_001404070 RefSeq | MGI Sequence Detail 4758 C57BL/6  
polypeptide Q3UJB9 UniProt | EBI | MGI Sequence Detail 1406 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006891 enhancer of mRNA-decapping protein 4
    (term hierarchy)
  • InterPro Domains
    IPR044938 Enhancer of mRNA-decapping protein 4, conserved C-terminal domain superfamily
    IPR049404 Enhancer of mRNA-decapping protein 4, C-terminal
    IPR045152 Enhancer of mRNA-decapping protein 4-like
    IPR032401 Enhancer of mRNA-decapping protein 4, WD40 repeat region
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q3UJB9 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 124
    cDNA 123
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory